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Current Topics Regarding the Function of the Medial Temporal Lobe Memory System
The first clear insight that the medial temporal lobe of the human brain was in fact a system of anatomically connected structures that were...
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A skin-specific α-Synuclein seeding amplification assay for diagnosing Parkinson’s disease
The seeding amplification assay (SAA) has recently emerged as a valuable tool for detecting α-synuclein (αSyn) aggregates in various clinically...
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New horizons for the role of selenium on cognitive function: advances and challenges
Cognitive deficits associated with oxidative stress and the dysfunction of the central nervous system are present in some neurodegenerative diseases,...
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Context-dependent reduction in corticomuscular coupling for balance control in chronic stroke survivors
Balance control is an important indicator of mobility and independence in activities of daily living. How the functional coupling between the cortex...
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Evidence of bottom-up homeostatic modulation induced taVNS during emotional and Go/No-Go tasks
Bilateral transcutaneous auricular vagus nerve stimulation (taVNS) - a non-invasive neuromodulation technique – has been investigated as a safe and...
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Cerebral White Matter Alterations Associated With Oligodendrocyte Vulnerability in Organic Acidurias: Insights in Glutaric Aciduria Type I
The white matter is an important constituent of the central nervous system, containing axons, oligodendrocytes, and its progenitor cells, astrocytes,...
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Activation of 5-HT6 Receptors in the Ventrolateral Orbital Cortex Produces Anti-Anxiodepressive Effects in a Rat Model of Neuropathic Pain
The comorbidity of anxiety and depression frequently occurs in patients with neuropathic pain. The ventrolateral orbital cortex (VLO) plays a...
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Scalp acupuncture guidance for identifying the optimal site for transcranial electrical stimulation of the hand
Transcranial electrical stimulation (tES) often targets the EEG-guided C3/C4 area that may not accurately represent M1 for hand muscles. This study...
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Perceptual decoupling in the sustained attention to response task is unlikely
Researchers dispute the cause of errors in high Go, low No Go target detection tasks, like the Sustained Attention to Response Task (SART). Some...
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Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body
BackgroundThe eye is a highly specialized sensory organ which encompasses the retina as a part of the central nervous system, but also non-neural...
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Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies
BackgroundIncreasing evidence supports the use of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation for diagnosis of...
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Cortical Generators and Connections Underlying Phoneme Perception: A Mismatch Negativity and P300 Investigation
The cortical generators of the pure tone MMN and P300 have been thoroughly studied. Their nature and interaction with respect to phoneme perception,...
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Integrating single-nucleus RNA sequencing and spatial transcriptomics to elucidate a specialized subpopulation of astrocytes, microglia and vascular cells in brains of mouse model of lipopolysaccharide-induced sepsis-associated encephalopathy
BackgroundUnderstanding the mechanism behind sepsis-associated encephalopathy (SAE) remains a formidable task. This study endeavors to shed light on...
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Long-Term High-Fat Diet Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta
As a risk factor for Alzheimer’s disease (AD), studies have demonstrated that long-term high-fat diet (HFD) could accelerate the deposition of...
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From Lab Bench to Hope: Emerging Gene Therapies in Clinical Trials for Alzheimer’s Disease
Alzheimer’s disease is a progressive neurodegenerative disorder that affects memory and cognitive abilities, affecting millions of people around the...
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Morphological and Molecular Characteristics of Perineuronal Nets in the Human Prefrontal Cortex—A Possible Link to Microcircuitry Specialization
Perineuronal nets (PNNs) are a type of extracellular matrix (ECM) that play a significant role in synaptic activity and plasticity of interneurons in...
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Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration
BackgroundLeveraging Alzheimer’s disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive...
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Developmental change of brain volume in Rett syndrome in Taiwan
ObjectiveRett syndrome (RTT) is characterized by neurological regression. This pioneering study investigated the effect of age on brain volume...
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Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer’s disease: Multimodal Preventive Trial for Alzheimer’s Disease (MIND-ADmini)
BackgroundMultimodal lifestyle interventions can benefit overall health, including cognition, in populations at-risk for dementia. However, little is...
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Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer’s continuum
BackgroundEnlarged choroid plexus (ChP) volume has been reported in patients with Alzheimer’s disease (AD) and inversely correlated with cognitive...
