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Preliminary field validity of ActiGraph-based energy expenditure estimation in wheelchair users with spinal cord injury
Study designCross-sectional validation study.
ObjectivesTo develop a raw acceleration signal-based random forest (RF) model for predicting total...
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Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fatigue syndrome: translating reduced oxygen consumption to impairment status to treatment considerations
BackgroundPost-exertional malaise (PEM), the hallmark symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), represents a...
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Participants’ perspectives of being recruited into a randomised trial of a weight loss intervention before colorectal cancer surgery: a qualitative interview study
BackgroundThe period between cancer diagnosis and surgery presents an opportunity for trials to assess the feasibility of behaviour change...
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Clinical outcome predictors for metastatic renal cell carcinoma: a retrospective multicenter real-life case series
Over the last decades, the therapeutic armamentarium of metastatic renal cell carcinoma (mRCC) has been revolutionized by the advent of...
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Exploring the causal association between uric acid and lung cancer in east Asian and European populations: a mendelian randomization study
BackgroundLung cancer still ranks first in the mortality rate of cancer. Uric acid is a product of purine metabolism in humans. Its presence in the...
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Hematopoietic stem cell transplantation for DLBCL: a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 years
Autologous(auto-) and allogeneic(allo-) hematopoietic stem cell transplantation (HSCT) are key treatments for relapsed/refractory diffuse large...
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A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation
The development of reliable methods for producing functional endothelial cells (ECs) is crucial for progress in vascular biology and regenerative...
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Towards targeting the breast cancer immune microenvironment
The tumour immune microenvironment is shaped by the crosstalk between cancer cells, immune cells, fibroblasts, endothelial cells and other stromal...
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At what risk? A research note on interviewer burden
BackgroundWe report on our methodological experiences during an investigation of how institutional racism functions in healthcare. We found tension...
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Effects of magnesium supplementation on muscle soreness in different type of physical activities: a systematic review
BackgroundMagnesium is a micronutrient and an intracellular cation responsible for different biochemical reactions involved in energy production and...
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HIV-protease inhibitors potentiate the activity of carfilzomib in triple-negative breast cancer
BackgroundResistance to chemotherapy is a major problem in the treatment of patients with triple-negative breast cancer (TNBC). Preclinical data...
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An In Silico Modelling Approach to Predict Hemodynamic Outcomes in Diabetic and Hypertensive Kidney Disease
Early diagnosis of kidney disease remains an unmet clinical challenge, preventing timely and effective intervention. Diabetes and hypertension are...
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Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease with a broad overlap of symptomatology with Post-COVID Syndrome...
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Interplay between WNT/PI3K-mTOR axis and the microbiota in APC-driven colorectal carcinogenesis: data from a pilot study and possible implications for CRC prevention
BackgroundWnt/β-catenin signalling impairment accounts for 85% of colorectal cancers (CRCs), including sporadic and familial adenomatous polyposis...
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EAF2 Downregulation Recruits Tumor-associated Macrophages in Prostate Cancer through Upregulation of MIF
BackgroundThe role of tumor inflammatory microenvironment in the advancement of cancer, particularly prostate cancer, is widely acknowledged....
