7 Result(s)
within
Zuzana Cierna
Cancer Research
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Article
Open AccessIncreased levels of XPA might be the basis of cisplatin resistance in germ cell tumours
Germ cell tumours (GCTs) represent a highly curable malignity as they respond well to cisplatin (CDDP)-based chemotherapy. Nevertheless, a small proportion of GCT patients relapse or do not respond to therapy....
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Article
Open Accessβcatenin is a marker of poor clinical characteristics and suppressed immune infiltration in testicular germ cell tumors
WNT/βcatenin (WNTβ) pathway is activated in early stages of embryonic development. We aimed to evaluate the significance of βcatenin in germ cell tumors (GCTs) and explore associations with the inflamed enviro...
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Article
Open AccessDecreased methylation in the SNAI2 and ADAM23 genes associated with de-differentiation and haematogenous dissemination in breast cancers
In breast cancer (BC), deregulation of DNA methylation leads to aberrant expressions and functions of key regulatory genes. In our study, we investigated the relationship between the methylation profiles of ge...
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Article
Open AccessALDH1A3 upregulation and spontaneous metastasis formation is associated with acquired chemoresistance in colorectal cancer cells
Efficiency of colorectal carcinoma treatment by chemotherapy is diminished as the resistance develops over time in patients. The same holds true for 5-fluorouracil, the drug used in first line chemotherapy of ...
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Article
Open AccessSystemic immune-inflammation index in germ-cell tumours
We evaluated systemic immune-inflammation index (SII) and its association with patient outcome in germ-cell tumours (GCTs).
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Article
Open AccessCombined enzyme/prodrug treatment by genetically engineered AT-MSC exerts synergy and inhibits growth of MDA-MB-231 induced lung metastases
Metastatic spread of tumor cells remains a serious problem in cancer treatment. Gene-directed enzyme/prodrug therapy mediated by tumor-homing genetically engineered mesenchymal stromal cells (MSC) represents a...
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Article
Open AccessMatrix metalloproteinase 1 and circulating tumor cells in early breast cancer
Matrix metalloproteinases (MMPs) are involved in cancer invasion and metastasis. Circulating tumor cells (CTCs) play role in tumor dissemination and are an independent survival predictor in breast cancer (BC) ...
