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    Article

    New triterpenoid saponins from Argania spinosa

    Five new triterpene saponins, arganine L (1), O (2), P (3), Q (4) and R (5), were isolated from the barks of Argania spinosa (L.) Skeels. Arganines L-P and R are bidesmosidic saponins. The structures of 15 were ...

    Nadia El Fakhar, Zoubida Charrouf, Bernadette Coddeville in Journal of Natural Medicines (2007)

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    Article

    Molecular drug design, synthesis and pharmacophore site identification of spiroheterocyclic compounds: Trypanosoma crusi inhibiting studies

    Synthesis and evaluation of the bioactivity of spiroheterocycles (STC) against Trypanosoma cruzi are described. Selectivity indices were improved for two compounds versus the leads 17 and 20, the spiro-thiochroma...

    Taibi Ben Hadda, Abdelali Kerbal, Brahim Bennani in Medicinal Chemistry Research (2013)

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    Article

    Computational POM and 3D-QSAR evaluation of experimental in vitro HIV-1-Integrase inhibition of amide-containing diketoacids

    A computation model has been developed for the rational design of bioactive pharmacophore sites as anti-viral candidates based on available X-ray structures of drugs. The compounds have been previously screene...

    Taibi Ben Hadda, Jihane Fathi, Imane Chafchaouni in Medicinal Chemistry Research (2013)