24 Result(s)
within
Zong** Cai
Analytical Chemistry
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Article
In situ fabrication of covalent organic frameworks on solid-phase microextraction probes coupled with electrospray ionization mass spectrometry for enrichment and determination of androgens in biosamples
Solid-phase microextraction (SPME) coupled with electrospray ionization mass spectrometry (ESI-MS) was developed for rapid and sensitive determination of endogenous androgens. The SPME probe is coated with cov...
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Article
Effects of pollutant toxicity on the eyes of aquatic life monitored by visual dysfunction in zebrafish: a review
The eyes of aquatic organisms may be damaged by exposure to pollutants. Zebrafish is a common laboratory model to study ocular toxicity, combining both fish and vertebrate characteristics. The toxic effects on...
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Article
Facile synthesis of hollow microtubular COF as enrichment probe for quantitative detection of ultratrace quinones in mice plasma with APGC-MS/MS
A hollow microtubular covalent organic framework (denoted as TatDha-COF) was synthesized by solvothermal method for the enrichment and determination of quinones. The TatDha-COF showed large specific surface ar...
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MIL-101(Fe)-derived magnetic porous carbon as sorbent for stir bar sorptive-dispersive microextraction of sulfonamides
Using MIL-101(Fe) as the source of carbon and Fe, a magnetic porous carbon (MPC) material with Fe3C nanoparticles encapsulated in porous carbon was prepared through one-pot pyrolysis under N2 atmosphere. With MPC...
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Facile fabrication of magnetic covalent organic frameworks and their application in selective enrichment of polychlorinated naphthalenes from fine particulate matter
Magnetic covalent organic frameworks (Fe3O4@TPPCl4) were synthesized via a one-pot process in which magnetic nanoparticles (Fe3O4@MNP) served as a magnetic core and 2,4,6-trihydroxy-1,3,5-benzenetricarbaldehyde (...
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Article
NAD tagSeq for transcriptome-wide identification and characterization of NAD+-capped RNAs
Several noncanonical initial nucleotides (NCINs) have been found to cap RNAs and possibly regulate RNA stability, transcription and translation. NAD+ is one of the NCINs that has recently been discovered to cap R...
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Article
High-throughput screening of bisphenols using magnetic covalent organic frameworks as a SELDI-TOF-MS probe
Core-shell structured magnetic covalent organic framework (Fe3O4@COF) nanospheres were rapidly synthesized at room temperature using the monodisperse Fe3O4 nanoparticles (NPs) as magnetic core and benzene-1,3,5-t...
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Article
Core-shell hollow spheres of type C@MoS2 for use in surface-assisted laser desorption/ionization time of flight mass spectrometry of small molecules
Mesoporous carbon hollow spheres coated with MoS2 (C@MoS2) were synthesized to obtain a material with large specific surface area, fast electron transfer efficiency and good water dispersibility. The composite ma...
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Article
Performance of atmospheric pressure gas chromatography-tandem mass spectrometry for the analysis of organochlorine pesticides in human serum
A novel method of atmospheric pressure gas chromatography-tandem mass spectrometry (APGC-MS/MS) for the analysis of organochlorine pesticides (OCPs) in human serum was developed. Better sensitivity and selecti...
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Article
Mesoporous graphitic carbon nitride as an efficient sorbent for extraction of sulfonamides prior to HPLC analysis
Mesoporous graphitic carbon nitride (MCN) is shown to be a viable sorbent for the enrichment of sulfonamides (SAs). To overcome the difficulty of separating the sorbent from the matrix, a novel type kind of co...
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Article
Analysis of Nitropolycyclic Aromatic Hydrocarbons in Fine Particulate Matter by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Using Fe3O4/ZIF-8 Magnetic Nanocomposites as Matrix
Core-shell magnetic metal organic nanocrystals were synthesized and used as matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Four nitropolycyclic aromatic...
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Article
MS-Based Metabolomics for the Investigation of Neuro-Metabolic Changes Associated with BDE-47 Exposure in C57BL/6 Mice
Polybrominated diphenyl ethers (PBDE), as one kind of the major persistent organic pollutants (POP), have potential adverse effects on human health. 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) has been identif...
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Article
Hippocampal metabolomics using ultrahigh-resolution mass spectrometry reveals neuroinflammation from Alzheimer’s disease in CRND8 mice
In the wake of genomics, metabolomics characterizes the small molecular metabolites revealing the phenotypes induced by gene mutants. To address the metabolic signatures in the hippocampus of the amyloid-beta ...
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Article
Newborn screening of phenylketonuria using direct analysis in real time (DART) mass spectrometry
Phenylketonuria (PKU) is commonly included in the newborn screening panel of most countries, with various techniques being used for quantification of l-phenylalanine (Phe). To diagnose PKU as early as possible in...
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Article
Proteomics investigation on aristolochic acid nephropathy: a case study on rat kidney tissues
Prolonged intake of aristolochic acid (AA) has been shown to be associated with the development of certain renal disorders. Renal tubular atrophy and interstitial fibrosis are the early symptoms of AA nephropa...
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Article
A method to enhance a1 ions and application for peptide sequencing and protein identification
A simple and effective method was developed for peptide sequencing and protein identification through the determination of its N-terminal residue. The method of N-terminal carbamidomethylation with iodoacetami...
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Identification of amino acid substitutions in avian influenza virus (H5N1) matrix protein 1 by using nanoelectrospray MS and MS/MS
Matrix protein 1 (M1), the major structural protein of the avian influenza virus, plays a critical role in regulation of viral RNA transcription via interaction with RNA and transportation of RNP cores. Mutati...
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Effect of tanshinone IIA on the noncovalent interaction between warfarin and human serum albumin studied by electrospray ionization mass spectrometry
Enhanced anticoagulation and/or even bleeding are often observed when patients on long-term warfarin (WAR) therapy consumed Danshen, a well-known medicinal herb in traditional Chinese medicine (TCM). This stud...
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Article
Site-specific binding of chelerythrine and sanguinarine to single pyrimidine bulges in hairpin DNA
Spectrofluorometric titration, electrospray ionization time-of-flight mass spectrometric and UV melting methods were employed to study the binding of chelerythrine and sanguinarine to bulged DNA. The results s...
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Liquid chromatography—tandem mass spectrometry analysis of the DNA adducts of aristolochic acids
Electrophilic attack of aristolactam-nitrenium ion by the C7 position to the exocyclic amino group in the DNA bases led to the formation of the major adducts. In this study, liquid chromatography coupled with ...
