10 Result(s)
within
Zong** Cai
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessMethionine restriction constrains lipoylation and activates mitochondria for nitrogenic synthesis of amino acids
Methionine restriction (MR) provides metabolic benefits in many organisms. However, mechanisms underlying the MR-induced effect remain incompletely understood. Here, we show in the budding yeast S. cerevisiae tha...
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Article
Open AccessArabidopsis DXO1 activates RNMT1 to methylate the mRNA guanosine cap
Eukaryotic messenger RNA (mRNA) typically contains a methylated guanosine (m7G) cap, which mediates major steps of mRNA metabolism. Recently, some RNAs in both prokaryotic and eukaryotic organisms have been found...
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Article
Open AccessKynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα
Activation of the kynurenine pathway (KP) has been reported in patients with pulmonary arterial hypertension (PAH) undergoing PAH therapy. We aimed to determine KP-metabolism in treatment-naïve PAH patients, i...
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Article
Open AccessThe cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer
Therapeutic targeting of KRAS-mutant colorectal cancer (CRC) is an unmet need. Here, we show that Proprotein Convertase Subtilisin/Kexin type 9 (PSCK9) promotes APC/KRAS-mutant CRC and is a therapeutic target. Us...
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Open AccessMicrobial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract
Emerging research supports that triclosan (TCS), an antimicrobial agent found in thousands of consumer products, exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models. While the ...
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Article
Open AccessHigher-generation type III-B rotaxane dendrimers with controlling particle size in three-dimensional molecular switching
Type III-B rotaxane dendrimers (T3B-RDs) are hyperbranched macromolecules with mechanical bonds on every branching unit. Here we demonstrate the design, synthesis, and characterization of first to third (G1–G3...
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Article
Open AccessAcetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
Besides the conventional carbon sources, acetyl-CoA has recently been shown to be generated from acetate in various types of cancers, where it promotes lipid synthesis and tumour growth. The underlying mechani...
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Article
Open AccessPlacental Transfer of Perfluoroalkyl Substances and Associations with Thyroid Hormones: Bei**g Prenatal Exposure Study
Perfluoroalkyl substances (PFASs) have been detected in wildlife and human samples worldwide. Toxicology research showed that PFASs could interfere with thyroid hormone homeostasis. In this study, eight PFASs,...
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Open AccessRegulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions
Cancer was hypothesized to be driven by cancer stem cells (CSCs), but the metabolic determinants of CSC-like phenotype still remain elusive. Here, we present that hexosamine biosynthetic pathway (HBP) at least...
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Open AccessComprehensive urinary metabolomic profiling and identification of potential noninvasive marker for idiopathic Parkinson’s disease
Urine metabolic phenoty** has been associated with the development of Parkinson’s disease (PD). However, few studies using a comprehensive metabolomics approach have investigated the correlation between chan...
