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  1. Article

    Open Access

    Clinical spectrum, over 12-year follow-up and experience of SGLT2 inhibitors treatment on patients with glycogen storage disease type Ib: a single-center retrospective study

    Glycogen storage disease type Ib (GSD Ib) is a rare disorder characterized by impaired glucose homeostasis caused by mutations in the SLC37A4 gene. It is a severe inherited metabolic disease associated with hypog...

    Yong-**an Shao, Cui-Li Liang, Ya-Ying Su, Yun-Ting Lin in Orphanet Journal of Rare Diseases (2024)

  2. No Access

    Article

    Prediction of histopathologic grades of myxofibrosarcoma with radiomics based on magnetic resonance imaging

    To develop a radiomics-based model from preoperative magnetic resonance imaging (MRI) for predicting the histopathological grades of myxofibrosarcoma.

    Yubin Yao, Yan Zhao, Lie**g Lu in Journal of Cancer Research and Clinical On… (2023)

  3. No Access

    Article

    Prenatal exposure to multiple environmental chemicals and birth size

    Epidemiological studies addressing the combined effects of exposure to chemical mixtures at different stages of pregnancy on birth size are scarce.

    Huan Chen, Wenxin Zhang, **aojie Sun in Journal of Exposure Science & Environmenta… (2023)

  4. Article

    Open Access

    Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids

    Horseshoe bats host numerous SARS-related coronaviruses without overt disease signs. Bat intestinal organoids, a unique model of bat intestinal epithelium, allow direct comparison with human intestinal organoi...

    **aojuan Liu, Cun Li, Zhixin Wan, Man Chun Chiu in Signal Transduction and Targeted Therapy (2022)

  5. Article

    Open Access

    Specific triacylglycerol, diacylglycerol, and lyso-phosphatidylcholine species for the prediction of type 2 diabetes: a ~ 16-year prospective study in Chinese

    Bioactive lipids play an important role in insulin secretion and sensitivity, contributing to the pathophysiology of type 2 diabetes (T2D). This study aimed to identify novel lipid species associated with inci...

    Junda Zhong, Chloe Y. Y. Cheung, **uli Su, Chi-Ho Lee, Yi Ru in Cardiovascular Diabetology (2022)

  6. Article

    Open Access

    A nomogram for bladder pain syndrome/interstitial cystitis based on netrin-1

    This study aimed to combine plasma netrin-1 and clinical parameters to construct a diagnostic model for bladder pain syndrome/interstitial cystitis (BPS/IC).

    **aojie Ang, Yufeng Jiang, Zongqiang Cai, Qi Zhou in International Urology and Nephrology (2022)

  7. No Access

    Chapter

    Biomechanics of Hip Joints

    Although the musculoskeletal system is complex, it follows the basic laws of mechanics. Biomechanics may be defined as studies of mechanics that act on biological organisms, to be specific in this context, hum...

    Hai Hu, Shi Zhan, Zongyuan Cai in Hip Surgery (2021)

  8. No Access

    Article

    Association between urinary paraben concentrations and gestational weight gain during pregnancy

    Parabens, a group of endocrine-disrupting chemicals, have been associated with obesity in previous studies. However, there is a paucity of literature regarding the effects of paraben exposures on gestational w...

    Qiu** Wen, Yanqiu Zhou, Youjie Wang in Journal of Exposure Science & Environmenta… (2020)

  9. Article

    Open Access

    CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis

    Metabolic dysfunction is a hallmark of gastric cancer (GC). In this study, we reported the identification of Calcium Binding Protein 39-Like (CAB39L) as a novel regulator of tumor metabolism in GC. CAB39L mRNA...

    Weilin Li, Chi Chun Wong, **aoming Zhang, Wei Kang, Geicho Nakatsu, Qinfu Zhao in Oncogene (2018)

  10. No Access

    Article

    Persistent Organic Pollutants as Risk Factors for Obesity and Diabetes

    The rising prevalence of obesity and diabetes cannot be fully explained by known risk factors, such as unhealthy diet, a sedentary lifestyle, and family history. This review summarizes the available studies li...

    Chunxue Yang, Alice Pik Shan Kong, Zongwei Cai in Current Diabetes Reports (2017)

  11. No Access

    Article

    Histone deacetylase inhibitors deplete myeloid-derived suppressor cells induced by 4T1 mammary tumors in vivo and in vitro

    Myeloid-derived suppressor cells (MDSC) have been identified as a population of immature myeloid cells that suppress anti-tumor immunity. MDSC are increased in tumor-bearing hosts; thus, depletion of MDSC may ...

    Hai-Fang Wang, Fen Ning, Zong-Cai Liu, Long Wu in Cancer Immunology, Immunotherapy (2017)

  12. Article

    Open Access

    Enhanced Detection of Early Hepatocellular Carcinoma by Serum SELDI-TOF Proteomic Signature Combined with Alpha-Fetoprotein Marker

    Biomarkers for accurate diagnosis of early hepatocellular carcinoma (HCC) are limited in number and clinical validation. We applied SELDI-TOF-MS ProteinChip technology to identify serum profile for distinguish...

    Lei Chen MD, David W. Y. Ho MPh, Nikki P. Y. Lee PhD in Annals of Surgical Oncology (2010)

  13. Article

    Open Access

    Biotransformation of ginsenosides Rb1, Rg3 and Rh2 in rat gastrointestinal tracts

    Ginsenosides such as Rb1, Rg3 and Rh2 are major bioactive components of Panax ginseng. This in vivo study investigates the metabolic pathways of ginsenosides Rb1, Rg3 and Rh2 orally administered to rats.

    Tianxiu Qian, Zongwei Cai in Chinese Medicine (2010)