126 Result(s)
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Open AccessInsight into binding of endogenous neurosteroid ligands to the sigma-1 receptor
The sigma-1 receptor (σ1R) is a non-opioid membrane receptor, which responds to a diverse array of synthetic ligands to exert various pharmacological effects. Meanwhile, candidates for endogenous ligands of σ1...
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Open AccessEnhancing efficiency of protein language models with minimal wet-lab data through few-shot learning
Accurately modeling the protein fitness landscapes holds great importance for protein engineering. Pre-trained protein language models have achieved state-of-the-art performance in predicting protein fitness w...
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Open AccessMacrophage-derived CD36 + exosome subpopulations as novel biomarkers of Candida albicans infection
Invasive candidiasis (IC) is a notable healthcare-associated fungal infection, characterized by high morbidity, mortality, and substantial treatment costs. Candida albicans emerges as a principal pathogen in this...
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Open AccessAuthor Correction: Waveguide-integrated twisted bilayer graphene photodetectors
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Open AccessExperimental study on fractal dimension of energy dissipation and crack growth in saturated tuff at different strain rates
In order to investigate the effects of strain rate and water saturation on the energy dissipation and crack growth of tuff, uniaxial compression tests were carried out on dry and water saturated tuff with diff...
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Open AccessResearch on safety condition assessment methodology for single tower steel box girder suspension bridges over the sea based on improved AHP-fuzzy comprehensive evaluation
In order to propose a reliable method for assessing the safety condition for single-tower steel box girder Suspension bridges over the sea, a condition monitoring system is established by installing sensors on...
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Open AccessConstruction of TiO2/WO3/TiO2 double heterojunction films for excellent electrochromic performance
Electrochromic devices are applied extensively to camouflages, smart windows, heat insulation layers, and automobile rearview mirrors, etc. The amorphous WO3 is a very attractive electrochromic material, whereas ...
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Open AccessFine-grained recognition of bitter gourd maturity based on Improved YOLOv5-seg model
Bitter gourd, being perishable, requires timely harvesting. Delayed harvesting can result in a substantial reduction in fruit quality. while premature harvesting leads to underdeveloped fruit and decreased yie...
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Open AccessCASi: A framework for cross-timepoint analysis of single-cell RNA sequencing data
Single-cell RNA sequencing (scRNA-seq) technology has been widely used to study the differences in gene expression at the single cell level, providing insights into the research of cell development, differenti...
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Open AccessDistributed electrified heating for efficient hydrogen production
This study introduces a distributed electrified heating approach that is able to innovate chemical engineering involving endothermic reactions. It enables rapid and uniform heating of gaseous reactants, facili...
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Open AccessWaveguide-integrated twisted bilayer graphene photodetectors
Graphene photodetectors have exhibited high bandwidth and capability of being integrated with silicon photonics (SiPh), holding promise for future optical communication devices. However, they usually suffer fr...
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Open AccessCD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age
Influenza B viruses (IBVs) cause substantive morbidity and mortality, and yet immunity towards IBVs remains understudied. CD8+ T-cells provide broadly cross-reactive immunity and alleviate disease severity by rec...
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Open AccessTopological perturbations on resilience of the world trade competition network
Network resilience refers to a system’s capability to adapt its functions to ensure continuity of essential operations amidst external environmental shifts or internal failures. The resilience of the world tra...
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Open AccessRoom-temperature stabilizing strongly competing ferrielectric and antiferroelectric phases in PbZrO3 by strain-mediated phase separation
PbZrO3 has been broadly considered as a prototypical antiferroelectric material for high-power energy storage. A recent theoretical study suggests that the ground state of PbZrO3 is threefold-modulated ferrielect...
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Open AccessIron status and sarcopenia-related traits: a bi-directional Mendelian randomization study
Although serum iron status and sarcopenia are closely linked, the presence of comprehensive evidence to establish a causal relationship between them remains insufficient. The objective of this study is to empl...
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Open AccessParameter optimization of vibration control system for adjacent building structures based on negative stiffness inerter damper
Building structures are subjected to strong earthquakes, which result in lateral collisions between them. Such collisions often cause severe structural damage and exacerbate the seismic hazard risk of building...
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Open AccessDigital inclusive finance, green technological innovation, and carbon emissions from a spatial perspective
Based on the panel data of 276 prefecture-level cities in China from 2011 to 2020, this study explores the impact of digital inclusive finance (DIF) on carbon emissions and the intrinsic mechanism of green tec...
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Open AccessPredicting the effect of chemicals on fruit using graph neural networks
The neural network method is a type of machine learning that has made significant advances over the past few years in a variety of fields, particularly text, speech, images, videos, etc. In areas where data is...
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Open AccessInvolution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway
Aging, chronic high-fat diet feeding, or housing at thermoneutrality induces brown adipose tissue (BAT) involution, a process characterized by reduction of BAT mass and function with increased lipid droplet si...
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Open AccessRecent autumn sea ice loss in the eastern Arctic enhanced by summer Asian-Pacific Oscillation
Recent rapid Arctic sea ice loss was documented as combined results from anthropogenic forcing and climate system internal variability. However, the role of internal variability is not well understood. Here, w...