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Article
Open AccessExploring the potential link between MitoEVs and the immune microenvironment of periodontitis based on machine learning and bioinformatics methods
Periodontitis is a chronic inflammatory condition triggered by immune system malfunction. Mitochondrial extracellular vesicles (MitoEVs) are a group of highly heterogeneous extracellular vesicles (EVs) enriche...
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Article
Open AccessPDGF-BB accelerates TSCC via fibroblast lactates limiting miR-26a-5p and boosting mitophagy
The tumor microenvironment and cancer-associated fibroblasts (CAFs) play crucial roles in tumor development, and their metabolic coupling remains unclear. Clinical data showed a positive correlation between PD...
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Article
Open AccessInterpretable discovery of semiconductors with machine learning
Machine learning models of material properties accelerate materials discovery, reproducing density functional theory calculated results at a fraction of the cost1–6. To bridge the gap between theory and experimen...
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Article
Open AccessPhoto-produced aromatic compounds stimulate microbial degradation of dissolved organic carbon in thermokarst lakes
Photochemical and biological degradation of dissolved organic carbon (DOC) and their interactions jointly contribute to the carbon dioxide released from surface waters in permafrost regions. However, the mecha...
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Article
Open AccessAntifungal activity, identification and biosynthetic potential analysis of fungi against Rhizoctonia cerealis
Wheat sheath blight mainly infected by Rhizoctonia cerealis is one of the soil-borne fungal diseases of wheat worldwide and prevalent in major wheat growing areas in China at present. This study aimed to evaluate...
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Article
SARS-CoV-2 has the advantage of competing the iMet–tRNAs with human hosts to allow efficient translation
To better understand the interaction between SARS-CoV-2 and human host and find potential ways to block the pandemic, one of the unresolved questions is that how the virus economically utilizes the resources o...
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Article
Open AccessControl of nanostructure and pinning properties in solution deposited YBa2Cu3O7−x nanocomposites with preformed perovskite nanoparticles
Solution deposited YBa2Cu3O7−x (YBCO) nanocomposites with preformed nanoparticles represent a promising cost-effective approach for superior critical current properties under applied magnetic fields. Nonetheless,...
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Article
Open AccessMagnitude of changes in patient symptom and medication scores in grass allergy immunotherapy trials: dependency on levels of pollen exposure
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Article
Open AccessEfficacy and safety of ragweed sublingual immunotherapy in Canadian patients with allergic rhinoconjunctivitis
Currently accepted therapies for ragweed allergy in North America consist of pharmacotherapy and subcutaneous allergen immunotherapy injections to treat symptoms. Allergen immunotherapy not only reduces sympto...
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Article
Open AccessThe efficacy and safety of the Timothy grass allergy sublingual immunotherapy tablet in Canadian adults and children
The effect of sublingual Timothy grass immunotherapy tablet 2800 BAU (grass SLIT-T) has been evaluated in three North American trials in adults and children who have allergic rhinitis with or without conjuncti...
