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Article
Process optimized for production of iturin A in biofilm reactor by Bacillus velezensis ND
In this research, to provide an optimal growth medium for the production of iturin A, the concentrations of key amino acid precursors were optimized in shake flask cultures using the response surface method. T...
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Article
A real-time object detection method for electronic screen GUI test systems
Automated testing of GUI elements on electronic screens by machine vision is widely used in smart manufacturing production lines. However, in the complex environment of factories, interference factors such as ...
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Article
2D metal azolate framework for efficient CO2 photoreduction
Visible-light-driven conversion of CO2 into value-added fuel is a clean and renewable technology to retard global warming and address energy shortages. Two-dimensional metal-azolate frameworks (2D MAFs) have rece...
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Article
DPHM-Net:de-redundant multi-period hybrid modeling network for long-term series forecasting
Deep learning models have been widely applied in the field of long-term forecasting has achieved significant success, with the incorporation of inductive bias such as periodicity to model multi-granularity rep...
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Article
Open AccessPenpulimab, an anti-PD-1 antibody, for heavily pretreated metastatic nasopharyngeal carcinoma: a single-arm phase II study
Penpulimab is an anti-programmed cell death-1 (PD-1) IgG1 antibody with no Fc gamma receptor (FcγR) binding activity, and thus theoretically reduced immune-related adverse events (irAEs) while maintaining effi...
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Article
Open AccessRadiomics of pericoronary adipose tissue on computed tomography angiography predicts coronary heart disease in patients with type 2 diabetes mellitus
Diabetes is a common chronic metabolic disease. The progression of the disease promotes vascular inflammation and the formation of atherosclerosis, leading to cardiovascular disease. The coronary artery periva...
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Article
Open AccessInhibition and transport mechanisms of the ABC transporter hMRP5
Human multidrug resistance protein 5 (hMRP5) effluxes anticancer and antivirus drugs, driving multidrug resistance. To uncover the mechanism of hMRP5, we determine six distinct cryo-EM structures, revealing an...
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Article
Solar-heated melamine sponge decorated with Fe3O4 for continuous recovery of viscous crude oil
The offshore crude oil spill has caused serious environmental damage and affected the balance of the ecosystem. Due to the high viscosity and poor fluidity of crude oil, conventional adsorbents cannot effectiv...
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Article
Time–Space Joint Response Characteristics of Acoustic Emission and Strain of Coal Damage Evolution
The occurrence of rockburst disasters is closely related to the zonal deformation and failure of rock masses. To effectively monitor and understand the critical zones of surrounding rock damage, it is imperati...
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Article
Dual-drug-loaded MSCs-derived exosomal vesicles inhibit endometrial cancer cell proliferation by promoting apoptosis through the migration and invasion of Rac1/NF-κB/MMP2 signalling pathway
Endometrial carcinoma affects the uterine lining. Endogenous activity, intrinsic targeting, and ability to engage with a host defence system make exosomal vehicles (EVs) a viable cancer treatment alternative. ...
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Article
Open AccessRemote sensing and its applications using GNSS reflected signals: advances and prospects
The Global Navigation Satellite Systems (GNSS), including the US’s GPS, China’s BDS, the European Union’s Galileo, and Russia’s GLONASS, offer real-time, all-weather, any-time, anywhere and high precision obse...
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Article
Open AccessBioinformatics analysis and experimental verification of the cancer-promoting effect of DHODH in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is a malignant tumor of the urinary system. To explore the potential mechanisms of DHODH in ccRCC, we analyzed its molecular characteristics using public databases. TCGA...
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Article
Cadonilimab with chemotherapy in HER2-negative gastric or gastroesophageal junction adenocarcinoma: the phase 1b/2 COMPASSION-04 trial
Treatment with anti-programmed cell death protein 1 (PD-1) therapy and chemotherapy prolongs the survival of patients with unresectable advanced or metastatic gastric or gastroesophageal junction (GEJ) adenoca...
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Article
Highly Selective CO2 Separation on Na-exchanged DNL-6 Synthesized by Utilization of Spent Industrial Catalyst
Conversion of industrial solid wastes into functional materials has attracted considerable interest, as it can reduce environmental pollution and facilitate the sustainable development of relevant processes. H...
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Article
Open AccessSustainable thermal regulation improves stability and efficiency in all-perovskite tandem solar cells
Mixed Sn-Pb perovskites have emerged as promising photovoltaic materials for both single- and multi-junction solar cells. However, achieving their scale-up and practical application requires further enhancemen...
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Article
Joint multi-server cache sharing and delay-aware task scheduling for edge-cloud collaborative computing in intelligent manufacturing
The rapid advancement of intelligent manufacturing has led to an increasing demand for computing resources in industrial computing tasks. As a new computing paradigm, edge-cloud collaborative computing (E3C) f...
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Article
Open AccessHypertonic saline- and detergent-accelerated EDTA-based decalcification better preserves mRNA of bones
Ethylenediaminetetraacetic acid (EDTA), a classically used chelating agent of decalcification, maintains good morphological details, but its slow decalcification limits its wider applications. Many procedures ...
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Article
Open AccessAn algorithm for cross-fiber separation in yarn hairiness image processing
Yarn hairiness affects yarn and fabric quality. The existing hairiness detection methods cannot discriminate crossover fibers or hairs. In order to accurately separate and detect crossover fibers, an algorithm...
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Article
Prediction of medial knee contact force using multisource fusion recurrent neural network and transfer learning
Estimation of knee contact force (KCF) during gait provides essential information to evaluate knee joint function. Machine learning has been employed to estimate KCF because of the advantages of low computatio...
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Article
Open AccessSafety and efficacy of umbilical cord tissue-derived mesenchymal stem cells in the treatment of patients with aging frailty: a phase I/II randomized, double-blind, placebo-controlled study
Mesenchymal stem cells (MSCs) hold a great promise for cell-based therapy in the field of regenerative medicine. In this study, we aimed to evaluate the safety and efficacy of intravenous infusion of human umb...
