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Article
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
The Wnt pathway has a central role in stem cell regulation. Gattinoni et al. now show that activation of the Wnt signaling cascade in naive CD8+ T cells blocks their differentiation into effector T cells and trig...
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Article
Erratum to: In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells
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Article
In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells
The T-lymphocyte pool can be subdivided into naïve (Tn), effector memory (Tem), and central memory (Tcm) T cells. In this study, we characterized in vitro short-term cultured anti-tumor human T lymphocytes gen...
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Article
A human memory T cell subset with stem cell–like properties
Whether there exists a human memory T cell population with stem cell–like properties of self-renewal and multipotency is under active investigation. Here Gattinoni et al. characterize a subset of human T cells th...
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Article
Open AccessPermissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68
Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. We previously described GLV-1h68, a modified Vaccinia Virus with exclusive tropism for tumor cells, and we ob...
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Article
Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells
The molecular basis of CD8+ memory is still being delineated. Gattinoni et al. show that the DNA-binding inhibitor Id3 is critical for the formation of long-lived memory.
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Article
Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails
The genetic modification of CD8+ T cells using anti-tumor T-cell receptors (TCR) or chimeric antigen receptors is a promising approach for the adoptive cell therapy of patients with cancer. We previously devel...
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Article
BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis
Diverse autoimmune and allergic diseases are associated with polymorphisms in a locus encoding the transcription factor BACH2; here, BACH2 is shown to be a broad regulator of immune activation that stabilizes ...
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Open AccessT cell receptor affinity and avidity defines antitumor response and autoimmunity in T cell immunotherapy
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Open AccessClinical scale zinc finger nuclease (ZFN)-driven gene-editing of PD-1 in tumor infiltrating lymphocytes (TIL) for the potential treatment of metastatic melanoma
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Open AccessEngineering the immune response to "self" for effective cancer immunotherapy
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Open AccessImmunotherapy generates selective pressure for acquisition of immunogenic neoantigens in escape tumors
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Article
BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers
T cell activation upon TCR signaling can lead to development of effector and memory cells. Roychoudhuri and colleagues show that the transcription factor BACH2 promotes memory CD8+ T cell generation by blocking a...
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Article
Ionic immune suppression within the tumour microenvironment limits T cell effector function
Potassium ions released by necrotic cells in tumours impair T cell function by increasing the intracellular potassium concentration in vitro and in vivo.
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Article
Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
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Article
Open AccessImmunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts
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Open AccessImmunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts
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Article
The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity
Stem cells are maintained by transcriptional programs that promote self-renewal and repress differentiation. Here, we found that the transcription factor c-Myb was essential for generating and maintaining stem...
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Article
Antisense targeting of CD47 enhances human cytotoxic T-cell activity and increases survival of mice bearing B16 melanoma when combined with anti-CTLA4 and tumor irradiation
Antibodies targeting the T-cell immune checkpoint cytotoxic T-lymphocyte antigen-4 (CTLA4) enhance the effectiveness of radiotherapy for melanoma patients, but many remain resistant. To further improve respons...
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Article
Open AccessIdentification of Small Molecule Enhancers of Immunotherapy for Melanoma
Small molecule based targeted therapies for the treatment of metastatic melanoma hold promise but responses are often not durable, and tumors frequently relapse. Response to adoptive cell transfer (ACT)-based ...
