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  1. No Access

    Article

    An engineered IL-2 partial agonist promotes CD8+ T cell stemness

    Adoptive transfer of antigen-specific T cells represents a major advance in cancer immunotherapy, with robust clinical outcomes in some patients1. Both the number of transferred T cells and their differentiation ...

    Fei Mo, Zhiya Yu, Peng Li, Jangsuk Oh, Rosanne Spolski, Liang Zhao… in Nature (2021)

  2. Article

    Open Access

    Identification of Small Molecule Enhancers of Immunotherapy for Melanoma

    Small molecule based targeted therapies for the treatment of metastatic melanoma hold promise but responses are often not durable, and tumors frequently relapse. Response to adoptive cell transfer (ACT)-based ...

    Christopher Dextras, Myagmarjav Dashnyam, Lesley A. Mathews Griner… in Scientific Reports (2020)

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  3. No Access

    Article

    Ionic immune suppression within the tumour microenvironment limits T cell effector function

    Potassium ions released by necrotic cells in tumours impair T cell function by increasing the intracellular potassium concentration in vitro and in vivo.

    Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff… in Nature (2016)

  4. No Access

    Article

    BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis

    Diverse autoimmune and allergic diseases are associated with polymorphisms in a locus encoding the transcription factor BACH2; here, BACH2 is shown to be a broad regulator of immune activation that stabilizes ...

    Rahul Roychoudhuri, Kiyoshi Hirahara, Kambiz Mousavi, David Clever… in Nature (2013)