5 Result(s)
within
Zhiya Yu
Infectious Diseases
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Article
The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity
Stem cells are maintained by transcriptional programs that promote self-renewal and repress differentiation. Here, we found that the transcription factor c-Myb was essential for generating and maintaining stem...
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Article
BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers
T cell activation upon TCR signaling can lead to development of effector and memory cells. Roychoudhuri and colleagues show that the transcription factor BACH2 promotes memory CD8+ T cell generation by blocking a...
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Article
Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells
The molecular basis of CD8+ memory is still being delineated. Gattinoni et al. show that the DNA-binding inhibitor Id3 is critical for the formation of long-lived memory.
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Article
A human memory T cell subset with stem cell–like properties
Whether there exists a human memory T cell population with stem cell–like properties of self-renewal and multipotency is under active investigation. Here Gattinoni et al. characterize a subset of human T cells th...
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Article
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
The Wnt pathway has a central role in stem cell regulation. Gattinoni et al. now show that activation of the Wnt signaling cascade in naive CD8+ T cells blocks their differentiation into effector T cells and trig...
