24 Result(s)
-
Article
Open AccessEffect of bridge height on airflow and aeolian sand flux near surface along the Qinghai-Tibet Railway, China
In this work, we studied the near-surface flow field structure of railway bridges with different heights through field investigation and wind tunnel simulation experiments. Meanwhile, we simulated the distribu...
-
Article
Open AccessSynthesis of borocarbonitride nanosheets from biomass for enhanced charge separation and hydrogen production
Borocarbonitride (BCN) materials have shown significant potential as photocatalysts for hydrogen production. However, traditional bulk BCN exhibits only moderate photocatalytic activity. In this study, we intr...
-
Article
Open AccessOrganization of corticocortical and thalamocortical top-down inputs in the primary visual cortex
Unified visual perception requires integration of bottom-up and top-down inputs in the primary visual cortex (V1), yet the organization of top-down inputs in V1 remains unclear. Here, we used optogenetics-assi...
-
Article
Open AccessOrganocatalytic skeletal reorganization for enantioselective synthesis of S-stereogenic sulfinamides
The enantioselective synthesis of S-stereogenic sulfinamides has garnered considerable attention due to their structural and physicochemical properties. However, catalytic asymmetric synthesis of sulfinamides sti...
-
Article
Open AccessFine-map** analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unkn...
-
Article
Open AccessDecreasing exciton dissociation rates for reduced voltage losses in organic solar cells
Enhancing the device electroluminescence quantum efficiency (EQEEL) is a critical factor in mitigating non-radiative voltage losses (VNR) and further improving the performance of organic solar cells (OSCs). While...
-
Article
Open AccessIdentification of a novel macrophage-related prognostic signature in colorectal cancer
Colorectal cancer (CRC) is one of the most prevalent and deadliest illnesses all around the world. Growing proofs demonstrate that tumor-associated macrophages (TAMs) are of critical importance in CRC pathogen...
-
Article
Open AccessNeutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages
The tumor microenvironment is reprogrammed by cancer cells and participates in all stages of tumor progression. Neutral ceramidase is a key regulator of ceramide, the central intermediate in sphingolipid metab...
-
Article
Open AccessCombining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European a...
-
Article
Open AccessEnantioselective organocatalytic synthesis of axially chiral aldehyde-containing styrenes via SNAr reaction-guided dynamic kinetic resolution
The precise and efficient construction of axially chiral scaffolds, particularly toward the aryl-alkene atropoisomers with impeccably full enantiocontrol and highly structural diversity, remains greatly challe...
-
Article
Open AccessEnantioconvergent construction of stereogenic silicon via Lewis base-catalyzed dynamic kinetic silyletherification of racemic chlorosilanes
Organosilanes possessing an enantioenriched stereogenic silicon center are important in many branches of chemistry, yet they remain challenging to synthesize in a practical and scalable way. Here we report a d...
-
Article
Open AccessData mining combines bioinformatics discover immunoinfiltration-related gene SERPINE1 as a biomarker for diagnosis and prognosis of stomach adenocarcinoma
Stomach adenocarcinoma (STAD) is a type of cancer which often at itsadvanced stage apon diagnosis and mortality in clinical practice. Several factors influencethe prognosis of STAD, including the expression an...
-
Article
Open AccessIntegrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers
Transcriptome-wide association studies (TWAS) have successfully discovered many putative disease susceptibility genes. However, TWAS may suffer from inaccuracy of gene expression predictions due to inclusion o...
-
Article
Open AccessUnveiling the charge transfer dynamics steered by built-in electric fields in BiOBr photocatalysts
Construction of internal electric fields (IEFs) is crucial to realize efficient charge separation for charge-induced redox reactions, such as water splitting and CO2 reduction. However, a quantitative understandi...
-
Article
Open AccessTetrahydroxy stilbene glycoside attenuates endothelial cell premature senescence induced by H2O2 through the microRNA-34a/SIRT1 pathway
Numerous studies have demonstrated that endothelial cell senescence plays a decisive role in the development and progression of cardiovascular diseases (CVD). Our previous results confirmed that Tetrahydroxy s...
-
Article
Open AccessPhoto-fluorination of nanodiamonds catalyzing oxidative dehydrogenation reaction of ethylbenzene
Styrene is one of the most important industrial monomers and is traditionally synthesized via the dehydrogenation of ethylbenzene. Here, we report a photo-induced fluorination technique to generate an oxidativ...
-
Article
Open AccessGenetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility
Identifying transcription factors (TFs) whose DNA bindings are altered by genetic variants that regulate susceptibility genes is imperative to understand transcriptional dysregulation in disease etiology. Here...
-
Article
Open AccessNoncovalently fused-ring electron acceptors with near-infrared absorption for high-performance organic solar cells
Non-fullerene fused-ring electron acceptors boost the power conversion efficiency of organic solar cells, but they suffer from high synthetic cost and low yield. Here, we show a series of low-cost noncovalentl...
-
Article
Open AccessCut Based Method for Comparing Complex Networks
Revealing the underlying similarity of various complex networks has become both a popular and interdisciplinary topic, with a plethora of relevant application domains. The essence of the similarity here is tha...
-
Article
Open AccessLocal Circulation Maintains the Coexistence of Lake-dune Pattern in the Badain Jaran Desert
Previous studies proposed various hypotheses to the formation of the mega-dunes and water recharge of the lakes in the Badain Jaran Desert but left the coexistence of lake-dune pattern unsolved. This research ...
