4 Result(s)
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Article
Open AccessOptogenetic activation of brainstem serotonergic neurons induces persistent pain sensitization
The rostral ventromedial medulla (RVM) is a key brainstem structure that conveys powerful descending influence of the central pain-modulating system on spinal pain transmission and processing. Serotonergic (5-...
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Article
Open AccessThe expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer’s disease
Recent evidence has suggested that Alzheimer’s disease (AD)-associated neuronal loss may occur via the caspase-independent route of programmed cell death (PCD) in addition to caspase-dependent mechanisms. Howe...
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Article
Open AccessTrafficking of central opioid receptors and descending pain inhibition
The delta-opioid receptor (DOR) belongs to the superfamily of G-protein-coupled receptors (GPCRs) with seven transmembrane domains, and its membrane trafficking is regulated by intracellular sorting processes ...
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Article
Open AccessIncreased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats
Currently, opioid-based drugs are the most effective pain relievers that are widely used in the treatment of pain. However, the analgesic efficacy of opioids is significantly limited by the development of tole...
