18 Result(s)
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Article
NRF2 Deficiency Promotes Ferroptosis of Astrocytes Mediated by Oxidative Stress in Alzheimer’s Disease
Oxidative stress is involved in the pathogenesis of Alzheimer’s disease (AD), which is linked to reactive oxygen species (ROS), lipid peroxidation, and neurotoxicity. Emerging evidence suggests a role of nucle...
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Serum Calcium, 25-Hydroxyvitamin D, and Parathyroid Hormone Levels in Relation to Aneurysmal Subarachnoid Hemorrhage
Elevated serum calcium (S-Ca), 25-hydroxyvitamin D (S-25OHD), and parathyroid hormone (S-PTH) levels have been associated with risk of aneurysmal subarachnoid hemorrhage (SAH) in observational studies. However...
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Article
Association of MicroRNA Biogenesis Genes Polymorphisms with Risk of Large Artery Atherosclerosis Stroke
Convincing evidence has shown that microRNAs (miRNAs) are involved in the pathogenesis of stroke. This study aimed to examine whether miRNA biogenesis genes polymorphisms are associated with risk of large arte...
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Article
Missense Variants in Hypoxia-Induced VEGFA/VEGFR2 Signaling Predict the Outcome of Large Artery Atherosclerotic Stroke
Collateral density variations are a major determinant of stroke outcome. Here, we explored the association of missense variants in hypoxia-induced VEGFA/VEGFR2 signaling and stroke outcome. We recruited 683 la...
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Article
Serum Creatinine Protects Against Amyotrophic Lateral Sclerosis: a Mendelian Randomization Study
Association between serum creatinine (sCr) and amyotrophic lateral sclerosis (ALS) has been reported in previous observational studies, but results are at risk of confounding bias and reverse causation. Theref...
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Spermidine Exhibits Protective Effects Against Traumatic Brain Injury
Traumatic brain injury (TBI) causes permanent neurological and cognitive impairments. Effective pharmacological interventions remain elusive. Spermidine is a polyamine compound found in our body that may play ...
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Article
Chromosome 4q25 Variants and Age at Onset of Ischemic Stroke
Recent genome-wide association studies have identified two variants rs10033464 and rs2200733 on chromosome 4q25, significantly associated with ischemic stroke risk. We conducted this study to investigate wheth...
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Article
Genetic Variants in MicroRNAs Predict Recurrence of Ischemic Stroke
MicroRNAs are a recently discovered class of small noncoding RNA, which play key roles in every aspect of brain function, including neural development and neurogenesis. Since abnormal expression and function o...
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Article
Fine-Map** of ABO Gene Identifies Two Novel SNPs Associated with Large Artery Atherosclerotic Stroke in a Chinese Han Population
Recently, a single nucleotide polymorphism (SNP) rs505922 in ABO gene was related to large artery atherosclerotic (LAA) stroke in Caucasian populations by genome-wide association study (GWAS). This study aimed...
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Article
Ontogenetic establishment of order-specific nuclear organization in the mammalian thalamus
Shi et al. performed a systematic clonal analysis and revealed an intricate ontogenetic logic of structural development and functional organization of the mammalian thalamus. Notably, neurons in cognitive versus ...
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Article
A Novel Functional Polymorphism in the NINJ2 Promoter Predicts Risk of Large Artery Atherosclerotic Stroke
A recent genome-wide association study (GWAS) identified two common polymorphisms (rs12425791 and rs11833579) on chromosome 12p13 that confer risk to stroke, particularly for large artery atherosclerotic (LAA)...
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Article
Chromosome 4q25 Variants rs2200733, rs10033464, and rs1906591 Contribute to Ischemic Stroke Risk
Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke. However, the results are inconsistent. Thus, we conducted thi...
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Article
PRKCH 1425G/A Polymorphism Predicts Recurrence of Ischemic Stroke in a Chinese Population
A recent genome-wide association study (GWAS) identified a nonsynonymous SNP (1425G/A) in PRKCH which was associated with increased risk of ischemic stroke. The purpose of this study was to examine whether this f...
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Article
A small-world-based population encoding model of the primary visual cortex
A wide range of evidence has shown that information encoding performed by the visual cortex involves complex activities of neuronal populations. However, the effects of the neuronal connectivity structure on t...
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Open AccessOptogenetic activation of brainstem serotonergic neurons induces persistent pain sensitization
The rostral ventromedial medulla (RVM) is a key brainstem structure that conveys powerful descending influence of the central pain-modulating system on spinal pain transmission and processing. Serotonergic (5-...
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Open AccessThe expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer’s disease
Recent evidence has suggested that Alzheimer’s disease (AD)-associated neuronal loss may occur via the caspase-independent route of programmed cell death (PCD) in addition to caspase-dependent mechanisms. Howe...
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Open AccessTrafficking of central opioid receptors and descending pain inhibition
The delta-opioid receptor (DOR) belongs to the superfamily of G-protein-coupled receptors (GPCRs) with seven transmembrane domains, and its membrane trafficking is regulated by intracellular sorting processes ...
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Article
Open AccessIncreased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats
Currently, opioid-based drugs are the most effective pain relievers that are widely used in the treatment of pain. However, the analgesic efficacy of opioids is significantly limited by the development of tole...
