5 Result(s)
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Article
Open AccessIncreased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats
Currently, opioid-based drugs are the most effective pain relievers that are widely used in the treatment of pain. However, the analgesic efficacy of opioids is significantly limited by the development of tole...
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Article
Open AccessTrafficking of central opioid receptors and descending pain inhibition
The delta-opioid receptor (DOR) belongs to the superfamily of G-protein-coupled receptors (GPCRs) with seven transmembrane domains, and its membrane trafficking is regulated by intracellular sorting processes ...
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Article
Epigenetic suppression of GAD65 expression mediates persistent pain
Identification of the mechanisms that drive the transition from acute to chronic pain could lead to new treatments. Now, Zhizhong Pan and colleagues demonstrate that chronic pain causes epigenetic downregulati...
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Article
Open AccessOptogenetic activation of brainstem serotonergic neurons induces persistent pain sensitization
The rostral ventromedial medulla (RVM) is a key brainstem structure that conveys powerful descending influence of the central pain-modulating system on spinal pain transmission and processing. Serotonergic (5-...
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Article
Stress–glucocorticoid–TSC22D3 axis compromises therapy-induced antitumor immunity
Psychological distress has long been suspected to influence cancer incidence and mortality. It remains largely unknown whether and how stress affects the efficacy of anticancer therapies. We observed that soci...
