9 Result(s)
within
Pharmacy
Zhi-**a Yang
-
Article
Aporphine alkaloids from Clematis parviloba and their antifungal activity
A new aporphine alkaloid, β-magnoflorine (1), together with a known aporphine alkaloid, α-magnoflorine (2), were isolated from the aerial parts of Clematis parviloba. Their structures were elucidated on the basis...
-
Article
Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks
To investigate the antiemetic effect of gingerol and its multi-targets effective mechanism on 5-hydroxytryptamine (5-HT), dopamine (DA) and substance P (SP). The antiemetic effect of gingerol was investigated ...
-
Article
Baicalin attenuates TNBS-induced colitis in rats by modulating the Th17/Treg paradigm
Baicalin, a flavonoid, has a wide range of pharmacological properties, including immunomodulation. The objective of this study was to investigate the effect of baicalin on the balance of T helper 17 (Th17) and...
-
Article
Structure-based design, structure–activity relationship analysis, and antitumor activity of diaryl ether derivatives
To identify novel therapeutic agents to treat cancer, we synthesized a series of diaryl ether derivatives. Structure–activity relationship studies revealed that the presence of a chlorine or hydroxyl at the pa...
-
Article
Icariin regulates PRMT/ADMA/DDAH pathway to improve endothelial function
Oxidative stress may affect PRMT/ADMA/DDAH (protein arginine methyltransferases/asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase) pathway to impair endothelial dysfunction. The present study...
-
Article
The attenuation of chlorogenic acid on oxidative stress for renal injury in streptozotocin-induced diabetic nephropathy rats
The present study was undertaken to investigate whether chlorogenic acid (CGA) could protect kidney function against oxidative stress in the diabetic nephropathy (DN) rats. The treatment with CGA could decreas...
-
Article
Kaempferol modulates Angiopoietin-like protein 2 expression to lessen the mastitis in mice
Mastitis is inflammation of a breast (or udder). Angiopoietin-like protein 2 (ANGPTL2) has been found as a key inflammatory mediator in mastitis. Purpose of this research was to investigate the mechanisms abou...
-
Article
Protective effects of l-theanine on rats with dextran sulfate sodium-induced inflammatory bowel disease
The aim of this study is to evaluate the anti-inflammatory and protective effects of l-theanine in inflammatory bowel disease (IBD) and to identify the underlying molecular mechanisms. Rats were pre-treated with
-
Article
Structures, biomimetic synthesis, and anti-SARS-CoV-2 activity of two pairs of enantiomeric phenylpropanoid-conjugated protoberberine alkaloids from the rhizomes of Corydalis decumbens
(±)-Decumicorine A (1) and (±)-epi-decumicorine A (2), two pairs of enantiomeric isoquinoline alkaloids featuring a novel phenylpropanoid-conjugated protoberberine skeleton, were isolated and purified from the rh...
