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  1. Article

    Open Access

    Unveiling the methionine cycle: a key metabolic signature and NR4A2 as a methionine-responsive oncogene in esophageal squamous cell carcinoma

    Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with notable metabolic reprogramming, yet the pivotal metabolic feature driving ESCC progression remains elusive. Here, we show that methionine ...

    **ng **, Lei Liu, Dan Liu, Jia Wu, Congcong Wang… in Cell Death & Differentiation (2024)

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  2. No Access

    Article

    Fbxo45 promotes the malignant development of esophageal squamous cell carcinoma by targeting GGNBP2 for ubiquitination and degradation

    Esophageal squamous cell carcinoma (ESCC) is one of the most common and deadly cancers. Fbxo45, a substrate recognition subunit of E3 ligase, is critically involved in tumorigenesis and tumor progression. Howe...

    Qi Wang, Linhui Wu, Ruoxue Cao, **g Gao, Damin Chai, Yanzi Qin, Li Ma… in Oncogene (2022)

  3. Article

    Open Access

    TM7SF2 regulates cell proliferation and apoptosis by activation of C-Raf/ERK pathway in cervical cancer

    Transmembrane 7 superfamily member 2 (TM7SF2) coding an enzyme involved in cholesterol metabolism has been found to be differentially expressed in kinds of tissues. Nevertheless, the role of TM7SF2 in the regu...

    Yichi Xu, **n Chen, Shuya Pan, Zhi-wei Wang, Xueqiong Zhu in Cell Death Discovery (2021)

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  4. Article

    Open Access

    The emerging role of WWP1 in cancer development and progression

    Emerging evidence demonstrates that WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) participates into carcinogenesis and tumor progression. In this review article, we will describe the association be...

    **aoli Hu, Jiangtao Yu, Zixia Lin, Renqian Feng, Zhi-wei Wang… in Cell Death Discovery (2021)

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  5. Article

    Open Access

    FBXO45 is a potential therapeutic target for cancer therapy

    FBXO protein 45 (FBXO45), a substrate-recognition subunit of E3 ligases, has been characterised to have pivotal roles in many human diseases, including nervous system diseases, inflammatory diseases and human ...

    Min Lin, Zhi-wei Wang, Xueqiong Zhu in Cell Death Discovery (2020)

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