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  1. Article

    Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis

    To explore the relationship between differential leucocyte count and coronary atherosclerosis.

    En-zhi Jia, Zhi-jian Yang, Biao Yuan, **ao-ling Zang in Acta Pharmacologica Sinica (2005)

  2. Article

    Electrophysiological effect of fluoxetine on Xenopus oocytes heterologously expressing human serotonin transporter

    To investigate the electrophysiological effect of fluoxetine on serotonin transporter.

    Hong-wei Wang, Ci-zhen Li, Zhi-fang Yang, Yan-qian Zheng in Acta Pharmacologica Sinica (2006)

  3. Article

    Induction of collateral artery growth and improvement of post-infarct heart function by hepatocyte growth factor gene transfer

    To study the effect of adenovirus5-mediated human hepatocyte growth factor (Ad5-HGF) transfer on post-infarct heart failure in a swine model.

    Wei Wang, Zhi-jian Yang, Dong-chao Ma, Lian-sheng Wang in Acta Pharmacologica Sinica (2006)

  4. Article

    Thrombolytic efficacy of native recombinant staphylokinase on femoral artery thrombus of rabbits

    To investigate the thrombolytic efficacy, ideal dosage and administration of native recombinant staphylokinase (r-SAK).

    Chun-jian Li, Jun Huang, Zhi-jian Yang, Ke-jiang Cao in Acta Pharmacologica Sinica (2007)

  5. Article

    Serum sodium concentration is significantly associated with the angiographic characteristics of coronary atherosclerosis

    To explore the relationship between serum sodium concentration and coronary atherosclerosis.

    En-zhi Jia, Zhi-jian Yang, Tie-bing Zhu, Lian-sheng Wang in Acta Pharmacologica Sinica (2007)

  6. Article

    Possible arrhythmiogenic mechanism produced by ibuprofen

    The aim of the present study was to investigate the electrophysiological effect of ibuprofen on the cardiac action potentials (AP) and electrocardiograms (ECG), and to identify its arrhythmiogenic mechanism.

    Zhi-fang Yang, Hong-wei Wang, Yan-qian Zheng, Yin Zhang in Acta Pharmacologica Sinica (2008)

  7. Article

    Association of human carboxypeptidase E exon5 gene polymorphisms with angiographical characteristics of coronary atherosclerosis in a Chinese population

    To explore the association between 801C>T and 847C>T polymorphisms of the human carboxypeptidase E (CPE) gene exon5, which could cause hyperproinsulinemia, and the angiographical characteristics of coronary at...

    Jie Wang, Yun Zhang, Zhi-jian Yang, Tie-bing Zhu in Acta Pharmacologica Sinica (2008)

  8. Article

    Association of serum sodium concentration with coronary atherosclerosis in China: follow-up study

    The aim of this study was to test the hypothesis that lower serum sodium may be associated with increased cardiovascular events and all-cause mortality by means of long-term follow-up of subjects with coronary...

    En-zhi Jia, Zhen-xia Xu, Zhi-jian Yang, Tie-bing Zhu in Acta Pharmacologica Sinica (2009)

  9. Article

    Beta-receptor activation increases sodium current in guinea pig heart

    To study the influence of β-receptor activation on sodium channel current and the physiological significance of increased sodium current with regard to the increased cardiac output caused by sympathetic excita...

    Hong-wei Wang, Zhi-fang Yang, Yin Zhang, Jian-min Yang in Acta Pharmacologica Sinica (2009)

  10. Article

    A novel acute anemia model for pharmacological research in mice by compelled acute exercise

    To generate a novel acute anemia model by compelled exercise.

    Qing-shan Liu, **-hua Wang, Jian Cui, Zhi-hong Yang in Acta Pharmacologica Sinica (2009)

  11. Article

    Point-of-care test of heart-type fatty acid-binding protein for the diagnosis of early acute myocardial infarction

    To investigate the efficacies of point-of-care test of heart-type fatty-acid binding protein (H-FABP) and its combinations with the conventional biomarkers in the diagnosis of early acute myocardial infarction...

    Chun-jian Li, Jie-qi Li, **ao-fang Liang, **ao-xiang Li in Acta Pharmacologica Sinica (2010)

  12. Article

    Electrophysiological mechanisms of sophocarpine as a potential antiarrhythmic agent

    To examine the electrophysiological effects of sophocarpine on action potentials (AP) and ionic currents of cardiac myocytes and to compare some of these effects with those of amiodarone.

    Zhi-fang Yang, Ci-zhen Li, Wei Wang, Ying-min Chen in Acta Pharmacologica Sinica (2011)

  13. Article

    Negative association between free triiodothyronine level and international normalized ratio in euthyroid subjects with acute myocardial infarction

    To investigate the relationship between free triiodothyronine (FT3) and the international normalized ratio (the ratio of the prothrombin time of a patient to the normal sample, INR) in Chinese euthyroid subjec...

    Li Li, Chang-yan Guo, **g Yang, En-zhi Jia, Tie-bing Zhu in Acta Pharmacologica Sinica (2011)

  14. Article

    Heterogeneity of chemosensitivity in esophageal cancer using ATP-tumor chemosensitivity assay

    Current chemotherapy for esophageal cancer is conducted on the basis of empirical information from clinical trials, which fails to take into account the known heterogeneity of chemosensitivity between patients...

    Zhi-qiang Ling, Chun-jian Qi, **ao-xiao Lu, Li-juan Qian in Acta Pharmacologica Sinica (2012)

  15. Article

    Pharmacokinetic and metabolomic analyses of the neuroprotective effects of salvianolic acid A in a rat ischemic stroke model

    Salvianolic acid A (SAA), a water-soluble phenolic acid isolated from the root of Dan Shen, displays distinct antioxidant activity and effectiveness in protection against cerebral ischemia/reperfusion (I/R) da...

    Si-qi Feng, Nan Aa, Jian-liang Geng, **g-qiu Huang in Acta Pharmacologica Sinica (2017)

  16. No Access

    Article

    Propofol decreases the excitability of cholinergic neurons in mouse basal forebrain via GABAA receptors

    Propofol is an intravenous anesthetic that can active γ-aminobutyric acid A (GABAA) receptors and generate sedative–hypnotic effects. Propofol has been widely applied clinically to achieve sedation comparable to ...

    Lei Chen, Zhi-lai Yang, Juan Cheng, **-** Zhang in Acta Pharmacologica Sinica (2019)

  17. No Access

    Article

    Crosstalk between the Akt/mTORC1 and NF-κB signaling pathways promotes hypoxia-induced pulmonary hypertension by increasing DPP4 expression in PASMCs

    Abnormal wound healing by pulmonary artery smooth muscle cells (PASMCs) promotes vascular remodeling in hypoxia-induced pulmonary hypertension (HPH). Increasing evidence shows that both the mammalian target of...

    Ying Li, Li Yang, Liang Dong, Zhi-wei Yang, **g Zhang in Acta Pharmacologica Sinica (2019)