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Article
Open AccessAMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...
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Article
DNAJ protein gene expansion mechanism in Panicoideae and PgDNAJ functional identification in pearl millet
Analyze the evolutionary pattern of DNAJ protein genes in the Panicoideae, including pearl millet, to identify and characterize the biological function of PgDNAJ genes in pearl millet.
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Article
Open AccessThe first two whole mitochondrial genomes for the genus Dactylis species: assembly and comparative genomics analysis
Orchardgrass (Dactylis glomerata L.), a perennial forage, has the advantages of rich leaves, high yield, and good quality and is one of the most significant forage for grassland animal husbandry and ecological ma...
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Article
Open AccessLow glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in co...
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Article
Thriving in the dynamics: a multi-level investigation of needs-supportive features, situational motivation, and employees’ subjective well-being
Employees often demonstrate various regulatory intentions toward multiple responsibilities they must fulfill on the job. Therefore, it is possible that employees’ motivation changes during the workday because ...
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Chapter
Ten Key Problems of Pre-trained Models: An Outlook of Representation Learning
The aforementioned representation learning methods have shown their effectiveness in various NLP scenarios and tasks. Large-scale pre-trained language models (i.e., big models) are the state of the art of repr...
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Chapter
Biomedical Knowledge Representation Learning
As a subject closely related to our life and understanding of the world, biomedicine keeps drawing much attention from researchers in recent years. To help improve the efficiency of people and accelerate the p...
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Article
Open AccessThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not ...
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Article
Open AccessLow-dose metformin targets the lysosomal AMPK pathway through PEN2
Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects1–4. For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role ...
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Article
Open AccessA deep-learning system bridging molecule structure and biomedical text with comprehension comparable to human professionals
To accelerate biomedical research process, deep-learning systems are developed to automatically acquire knowledge about molecule entities by reading large-scale biomedical data. Inspired by humans that learn d...
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Article
Open AccessA role for neutrophils in early enthesitis in spondyloarthritis
Neutrophils are present in the early phases of spondyloarthritis-related uveitis, skin and intestinal disease, but their role in enthesitis, a cardinal musculoskeletal lesion in spondyloarthritis, remains unkn...
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Chapter and Conference Paper
Natural Language Processing Using Database Context
The usage of natural language in the industry has become more prevalent in recent years. Nowadays it is much easier to operate with complex infrastructures using natural language. This subfield of artificial i...
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Article
Open AccessImproved cold tolerance in switchgrass by a novel CCCH-type zinc finger transcription factor gene, PvC3H72, associated with ICE1–CBF–COR regulon and ABA-responsive genes
Switchgrass (Panicum virgatum) is a warm-season perennial grass. Improving its cold tolerance is important for its sustainable production in cooler regions. Through genome-wide bioinformatic analysis of switchgra...
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Article
Transcriptome analysis of Cd-treated switchgrass root revealed novel transcripts and the importance of HSF/HSP network in switchgrass Cd tolerance
Transcriptome analysis of Cd-treated switchgrass roots not only revealed novel switchgrass transcripts and gene structures but also highlighted the indispensable role of HSF/HSP network in switchgrass Cd toler...
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Article
Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications
Patients with rheumatoid arthritis (RA) have historically developed progressive damage of articular bone and cartilage, which correlates with disability over time. In addition, these patients are prone to peri...
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Article
Influence of the pelletizing process parameters on the breakage behaviour of the received alumina oxide pellets
Pelletizing is a common optimization process of the mechanical properties of various powder materials. The improvement of flow behaviour, dosage and the increase of bulk density are only a few the goals that t...
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Article
Open AccessSwitchgrass PvDREB1C plays opposite roles in plant cold and salt tolerance in transgenic tobacco
The C-repeat-binding factors/DRE-binding factors (CBF/DREBs) comprise a key transcription factor family involved in plant stress tolerance. Yet, there is limited information about switchgrass DREB genes and th...
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Article
Open AccessAn efficient protocol for perennial ryegrass mesophyll protoplast isolation and transformation, and its application on interaction study between LpNOL and LpNYC1
Perennial ryegrass (Lolium perenne L.) is an important temperate grass used for turf and forage purposes. With the increasing accumulation of genomic and transcriptomic data of perennial ryegrass, an efficient pr...
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Article
Differential Effects of Inflammation on Bone and Response to Biologics in Rheumatoid Arthritis and Spondyloarthritis
We review the pathways, cytokines, and concepts important to the pathogenesis of bone resorption and formation in rheumatoid arthritis (RA) and spondyloarthritis (SpA).
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Article
Cardiolipin remodeling: a regulatory hub for modulating cardiolipin metabolism and function
Cardiolipin (CL), the signature phospholipid of mitochondria, is involved in a plethora of cellular processes and is crucial for mitochondrial function and architecture. The de novo synthesis of CL in the mitocho...
