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Article
Effects of Commonly used Surfactants, Poloxamer 188 and Tween 80, on the Drug Transport Capacity of Intestinal Glucose Transporters
Some glycoside drugs can be transported through intestinal glucose transporters (IGTs). The surfactants used in oral drug preparations can affect the function of transporter proteins. This study aimed to inves...
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Article
Open AccessComparison of gut transcriptome and bacterial composition of the yellow peach moth, Conogethes punctiferalis larvae associated with host plants adaptation
The yellow peach moth, Conogethes punctiferalis, is one of the most destructive polyphagous pests to corn crops in the Huang-Huai-Hai summer corn region of China. However, little is known about the host plant ada...
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Article
Effects of Three Kinds of Carbohydrate Pharmaceutical Excipients—Fructose, Lactose and Arabic Gum on Intestinal Absorption of Gastrodin through Glucose Transport Pathway in Rats
Some glucoside drugs can be transported via intestinal glucose transporters (IGTs), and the presence of carbohydrate excipients in pharmaceutical formulations may influence the absorption of them. This study, ...
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Article
Brain network centrality and connectivity are associated with clinical subtypes and disease progression in Parkinson’s disease
To investigate brain network centrality and connectivity alterations in different Parkinson’s disease (PD) clinical subtypes using resting-state functional magnetic resonance imaging (RS-fMRI), and to explore ...
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Article
A comparative study on the preparation and evaluation of solubilizing systems for silymarin
Silymarin (SM) exhibits clinical efficacy in treating liver injuries, cirrhosis, and chronic hepatitis. However, its limited water solubility and low bioavailability hinder its therapeutic potential. The prima...
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Article
BR regulates wheat root salt tolerance by maintaining ROS homeostasis
Trace amounts of epibrassinolide (EpiBL) could partially rescue wheat root length inhibition in salt-stressed situation by scavenging ROS, and ectopic expression of TaDWF4 or TaBAK1 enhances root salt tolerance ...
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Article
Open AccessTREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson’s Disease Mice and LPS-Induced BV2 Cells
Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD). Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective effects in PD ...
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Article
Open AccessDLD is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients
Since the discovery of copper induces cell death(cuprotosis) in 2022, it has been one of the biggest research hotspots. cuprotosis related genes (CRGs) has been demonstrated to be a potential therapeutic targe...
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Article
Open AccessHuman emergency behaviour and psychological stress characteristic mining based on large-scale emergencies
Human emergency behaviour and psychological stress response in emergencies are important scientific issues in basic emergency management research. The analysis of the dynamic characteristics of large-scale hum...
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Article
Open AccessCrosstalk between colorectal CSCs and immune cells in tumorigenesis, and strategies for targeting colorectal CSCs
Cancer immunotherapy has emerged as a promising strategy in the treatment of colorectal cancer, and relapse after tumor immunotherapy has attracted increasing attention. Cancer stem cells (CSCs), a small subse...
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Article
The High-tech Enterprise Certification Policy and Innovation: Quantity or Quality?
The debate on industrial policy is a hot issue in both academic studies and policy practices. Empirical evidence on the relationship between the high-tech enterprise certification policy and innovation is mixe...
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Article
Research on optimization method of stainless steel sawing process parameters based on multi-tooth sawing force prediction model
In this study, a multi-tooth sawing force prediction model is proposed for the stainless steel sawing process, combined with the classical cutting theory of band saw and the introduction of tooth equivalent cu...
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Article
Distinct Mechanisms for Channel Segregation in Ultra-Heavy Advanced Steel Ingots via Numerical Simulation and Experimental Characterization
Channel segregation is one of the most common defects in solidifying steel, particularly in ultra-heavy advanced steel ingots, and it has a significant effect on the mechanical properties of the final products...
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Article
Thermo-mechanics Driven Dynamic Recrystallization Behavior and Mechanism in High Strength Martensitic Stainless Steel
The hot deformation behavior and dynamic recrystallization mechanism of a new High Strength Martensitic Stainless Steel (HSMSS) for aero bearing were systematically studied by the single-pass isothermal compre...
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Article
Pneumatically Operated Piston Shock Calibrator for Acceleration Sensors
Abstract—In order to provide fast, accurate, and low cost shock sensitivity calibration of acceleration sensors, a pneumatically operated piston shock calibrator based on ISO 16063-22 is designed. comparative cal...
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Article
Open AccessAuthor Correction: Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4
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Article
Open AccessThe updates and implications of cutaneous microbiota in acne
Acne is a chronic inflammatory skin disorder that profoundly impacts the quality of life of patients worldwide. While it is predominantly observed in adolescents, it can affect individuals across all age group...
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Article
Open AccessMolecular basis for Eaf3-mediated assembly of Rpd3S and NuA4
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Article
Open AccessAbnormal cerebellum connectivity patterns related to motor subtypes of Parkinson’s disease
Cerebellar dysfunction may substantially contribute to the clinical symptoms of Parkinson’s disease (PD). The role of cerebellar subregions in tremors and gait disturbances in PD remains unknown. To investigat...
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Article
Open AccessmcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs
Liver tumour-initiating cells (TICs) contribute to tumour initiation, metastasis, progression and drug resistance. Metabolic reprogramming is a cancer hallmark and plays vital roles in liver tumorigenesis. How...
