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Open AccessComparison of gut transcriptome and bacterial composition of the yellow peach moth, Conogethes punctiferalis larvae associated with host plants adaptation
The yellow peach moth, Conogethes punctiferalis, is one of the most destructive polyphagous pests to corn crops in the Huang-Huai-Hai summer corn region of China. However, little is known about the host plant ada...
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Article
Open AccessTREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson’s Disease Mice and LPS-Induced BV2 Cells
Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD). Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective effects in PD ...
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Article
Open AccessDLD is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients
Since the discovery of copper induces cell death(cuprotosis) in 2022, it has been one of the biggest research hotspots. cuprotosis related genes (CRGs) has been demonstrated to be a potential therapeutic targe...
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Article
Open AccessHuman emergency behaviour and psychological stress characteristic mining based on large-scale emergencies
Human emergency behaviour and psychological stress response in emergencies are important scientific issues in basic emergency management research. The analysis of the dynamic characteristics of large-scale hum...
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Article
Open AccessCrosstalk between colorectal CSCs and immune cells in tumorigenesis, and strategies for targeting colorectal CSCs
Cancer immunotherapy has emerged as a promising strategy in the treatment of colorectal cancer, and relapse after tumor immunotherapy has attracted increasing attention. Cancer stem cells (CSCs), a small subse...
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Open AccessAuthor Correction: Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4
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Article
Open AccessThe updates and implications of cutaneous microbiota in acne
Acne is a chronic inflammatory skin disorder that profoundly impacts the quality of life of patients worldwide. While it is predominantly observed in adolescents, it can affect individuals across all age group...
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Open AccessMolecular basis for Eaf3-mediated assembly of Rpd3S and NuA4
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Article
Open AccessAbnormal cerebellum connectivity patterns related to motor subtypes of Parkinson’s disease
Cerebellar dysfunction may substantially contribute to the clinical symptoms of Parkinson’s disease (PD). The role of cerebellar subregions in tremors and gait disturbances in PD remains unknown. To investigat...
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Article
Open AccessmcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs
Liver tumour-initiating cells (TICs) contribute to tumour initiation, metastasis, progression and drug resistance. Metabolic reprogramming is a cancer hallmark and plays vital roles in liver tumorigenesis. How...
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Article
Open AccessNanowarming and ice-free cryopreservation of large sized, intact porcine articular cartilage
Successful organ or tissue long-term preservation would revolutionize biomedicine. Cartilage cryopreservation enables prolonged shelf life of articular cartilage, posing the prospect to broaden the implementat...
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Article
Open AccessTumor immune cell infiltration score based model predicts prognosis in multiple myeloma
The tumor microenvironment plays an important role in various processes, including tumorigenesis, cancer progression, and metastasis. Immune signatures have been identified and verified for use in diagnosis an...
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Article
Correction: LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation
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Open AccessDysfunction of the energy sensor NFE2L1 triggers uncontrollable AMPK signaling and glucose metabolism reprogramming
The antioxidant transcription factor NFE2L1 (also called Nrf1) acts as a core regulator of redox signaling and metabolism homeostasis, and thus, its dysfunction results in multiple systemic metabolic diseases....
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Open AccessCorrection: MiR-193b-3p–ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes
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Open AccessMiR-193b-3p–ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes
Psoriasis is an auto-inflammatory skin disease characterized by abnormal activation of epidermal keratinocytes, aberrant neovascularization, and dysregulation of immune cells. MicroRNAs are small non-coding RN...
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Open Accessd-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens
d-Serine is a crucial endogenous co-agonist of N-methyl-d-aspartate receptors (NMDARs) in the central nervous system and can affect the function of the brain derived neurotrophic factor (BDNF) system, which plays...
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Article
Open AccessOpportunities and challenges of glioma organoids
Glioma is the most common primary brain tumor and its prognosis is poor. Despite surgical removal, glioma is still prone to recurrence because it grows rapidly in the brain, is resistant to chemotherapy, and i...
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Article
Open AccessAmnion signals are essential for mesoderm formation in primates
Embryonic development is largely conserved among mammals. However, certain genes show divergent functions. By generating a transcriptional atlas containing >30,000 cells from post-implantation non-human primat...
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Correction to: Effect of Surface Property on the Release and Oral Absorption of Solid Sirolimus-Containing Self-Microemulsifying Drug Delivery System
A Correction to this paper has been published: https://doi.org/10.1208/s12249-021-01997-w