11 Result(s)

Article

TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson’s Disease Mice and LPS-Induced BV2 Cells

Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD). Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective effects in PD ...

Peiting Huang, Zhanyu Zhang, Piao Zhang, Jiezhu Feng, Jianwei **e… in Molecular Neurobiology (2024)

Article

DLD is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients

Since the discovery of copper induces cell death(cuprotosis) in 2022, it has been one of the biggest research hotspots. cuprotosis related genes (CRGs) has been demonstrated to be a potential therapeutic targe...

Can Chen, Dandan Kang, Zhenzhen Chen, Pengfei Shi, Yun Li, Shenxian Qian in Apoptosis (2024)

Article

Author Correction: Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4

Zhenzhen Chen, Taylor Lundy, Zhongliang Zhu, Victoria E. Hoskins… in Cell Discovery (2023)

Article

The updates and implications of cutaneous microbiota in acne

Acne is a chronic inflammatory skin disorder that profoundly impacts the quality of life of patients worldwide. While it is predominantly observed in adolescents, it can affect individuals across all age group...

Cong Huang, Fan Zhuo, Baoquan Han, Wenting Li, Bin Jiang… in Cell & Bioscience (2023)

Article

Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4

Zhenzhen Chen, Taylor Lundy, Zhongliang Zhu, Victoria E. Hoskins… in Cell Discovery (2023)

Article

Correction: LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation

Zhenzhen Chen, Yanfeng Gao, Lintong Yao, Yating Liu, Lan Huang, Zhongyi Yan… in Oncogene (2022)

Article

Dysfunction of the energy sensor NFE2L1 triggers uncontrollable AMPK signaling and glucose metabolism reprogramming

The antioxidant transcription factor NFE2L1 (also called Nrf1) acts as a core regulator of redox signaling and metabolism homeostasis, and thus, its dysfunction results in multiple systemic metabolic diseases....

Lu Qiu, Qiufang Yang, Wenshan Zhao, Yadi **ng, Peng Li… in Cell Death & Disease (2022)

Article

Correction: MiR-193b-3p–ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes

Cong Huang, Weilong Zhong, Xuanyao Ren, **a Huang, Zizhuo Li… in Cell Death & Disease (2021)

Article

MiR-193b-3p–ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes

Psoriasis is an auto-inflammatory skin disease characterized by abnormal activation of epidermal keratinocytes, aberrant neovascularization, and dysregulation of immune cells. MicroRNAs are small non-coding RN...

Cong Huang, Weilong Zhong, Xuanyao Ren, **a Huang, Zizhuo Li… in Cell Death & Disease (2021)

Article

Opportunities and challenges of glioma organoids

Glioma is the most common primary brain tumor and its prognosis is poor. Despite surgical removal, glioma is still prone to recurrence because it grows rapidly in the brain, is resistant to chemotherapy, and i...

**angdong Xu, Lingfei Li, Linting Luo, Lingling Shu… in Cell Communication and Signaling (2021)

Article

LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation

Liver tumor-initiating cells (TICs), the drivers for liver tumorigenesis, accounts for liver tumor initiation, metastasis, drug resistance and relapse. Wnt/β-catenin signaling pathway emerges as a critical mod...

Zhenzhen Chen, Yanfeng Gao, Lintong Yao, Yating Liu, Lan Huang, Zhongyi Yan… in Oncogene (2018)