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  1. Article

    Open Access

    Specific Mode Electroacupuncture Stimulation Mediates the Delivery of NGF Across the Hippocampus Blood–Brain Barrier Through p65-VEGFA-TJs to Improve the Cognitive Function of MCAO/R Convalescent Rats

    Cognitive impairment frequently presents as a prevalent consequence following stroke, imposing significant burdens on patients, families, and society. The objective of this study was to assess the effectivenes...

    Mengyuan Dai, Kecheng Qian, Qinyu Ye, **ding Yang, Lin Gan in Molecular Neurobiology (2024)

  2. Article

    Open Access

    STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma

    Esophageal squamous cell carcinoma (ESCC) is an aggressive disease with a poor prognosis, caused by the inactivation of critical cell growth regulators that lead to uncontrolled proliferation and increased mal...

    Ziying Zhao, Yuan Chu, Anqi Feng, Shihan Zhang, Hao Wu, Zhaoxing Li in Cellular Oncology (2024)

  3. Article

    Open Access

    Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia

    Cisplatin (DDP)-based chemotherapy is commonly adopted as the first-line treatment for patients with oesophageal squamous cell carcinoma (OSCC), but the high rate of drug resistance limits its clinical applica...

    Kang Fang, Mingchuang Sun, Zhuyun Leng in Journal of Experimental & Clinical Cancer … (2023)

  4. No Access

    Article

    Supraspinal neural mechanisms of the analgesic effect produced by transcutaneous electrical nerve stimulation

    Although the analgesic effects of conventional transcutaneous electrical nerve stimulation (TENS) and acupuncture-like TENS are evident, their respective neural mechanisms in humans remain controversial. To el...

    Yanzhi Bi, Zhaoxing Wei, Yazhuo Kong, Li Hu in Brain Structure and Function (2021)

  5. Article

    Correction to: Ghrelin ameliorates nerve growth factor Dysmetabolism and inflammation in STZ-induced diabetic rats

    In the original published article: A wrong GFAP immunohistochemistry staining image was inadvertently chosen to present as Control group image (the published Fig.1B).

    Yuxing Zhao, Zhaoxing Shen, Dongling Zhang, Huiqiong Luo in Metabolic Brain Disease (2020)

  6. Article

    Open Access

    High-Dose Paraquat Induces Human Bronchial 16HBE Cell Death and Aggravates Acute Lung Intoxication in Mice by Regulating Keap1/p65/Nrf2 Signal Pathway

    Paraquat (PQ) intoxication seriously endangers human beings’ health, however, the underlying mechanisms are still unclear. Here we found that PQ inhibits human bronchial 16HBE cell proliferation and promotes c...

    Jiexiong Yao, Jihua Zhang, Wenlin Tai, Shuhao Deng, Ting Li, Wenjuan Wu in Inflammation (2019)

  7. No Access

    Article

    Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids

    The diversity of the bacterial community in the gut is closely related to human health. Gut microbes accomplish multiple physiological and biochemical functions. Sitosterols are a series of phytochemicals that...

    Hang Ma, Yang Yu, Meimei Wang, Zhaoxing Li, Heshan Xu, Cheng Tian, Jian Zhang in Apoptosis (2019)

  8. No Access

    Article

    Ghrelin ameliorates nerve growth factor Dysmetabolism and inflammation in STZ-induced diabetic rats

    Diabetic encephalopathy is characterized by cognitive impairment and neuroinflammation, deficient neurotrophic support, and neuronal and synaptic loss. Ghrelin, a 28 amino acid peptide, is associated with neur...

    Yuxing Zhao, Zhaoxing Shen, Dongling Zhang, Huiqiong Luo in Metabolic Brain Disease (2017)