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  1. Article

    Open Access

    Phenotypic and genetic analysis of children with unexplained neurodevelopmental delay and neurodevelopmental comorbidities in a Chinese cohort using trio-based whole-exome sequencing

    Trio-based whole-exome sequencing (trio-WES) enables identification of pathogenic variants, including copy-number variants (CNVs), in children with unexplained neurodevelopmental delay (NDD) and neurodevelopme...

    Ruohao Wu, **aojuan Li, Zhe Meng, **gan Li in Orphanet Journal of Rare Diseases (2024)

  2. Article

    Open Access

    SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication

    Viral infection in respiratory tract usually leads to cell death, impairing respiratory function to cause severe disease. However, the diversity of clinical manifestations of SARS-CoV-2 infection increases the...

    Pan Pan, Weiwei Ge, Zhiwei Lei, Wei luo in Signal Transduction and Targeted Therapy (2023)

  3. Article

    Open Access

    Clinical significance of nonerythrocytic spectrin Beta 1 (SPTBN1) in human kidney renal clear cell carcinoma and uveal melanoma: a study based on Pan-Cancer Analysis

    Nonerythrocytic spectrin beta 1 (SPTBN1) is an important cytoskeletal protein that involves in normal cell growth and development via regulating TGFβ/Smad signaling pathway, and is aberrantly expressed in vari...

    Wenting Tang, Qiong Shao, Zhanwen He, Xu Zhang, **aojuan Li, Ruohao Wu in BMC Cancer (2023)

  4. Article

    Open Access

    MiR-106b-5p regulates esophageal squamous cell carcinoma progression by binding to HPGD

    Several studies have documented the key role of microRNAs (miRNAs) in esophageal squamous cell carcinoma (ESCC). Although the expression of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene and miR-106b-5p ar...

    Fan Yang, Zhanwen Sun, Dengyun Wang, Tian Du in BMC Cancer (2022)

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    Book

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    Chapter

    Principles of Acupuncture Therapeutics

    The general principles of acupuncture treatment evolved through millennia of acupuncture-moxibustion practice as guided by the theories of CM. In turn, they guide the choice of acupuncture-moxibustion treatmen...

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Formation of the Chinese Medicine Theoretical System and Its Philosophical Basis

    Chinese Medicine (CM) has had a history of several thousand years. It is the crystallization of the rich experiences in the Chinese people's long struggle against diseases. The many years have fostered the gra...

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Neurodermatitis

    Neurodermatitis is a chronic skin condition characterized by frequent episodic attacks of itch and lichenification.

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Facial Boils

    A facial boil is an acute suppurative lesion on any part of the face. The head is where all the Yang Meridians converge, so that the poisons of Fire readily accumulate there and illnesses can develop rapidly. ...

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Constipation

    Constipation means either feces remaining overlong in the large intestine, so that the interval between defecations is prolonged, or difficult or painful defecation due to dry, large or hard feces.

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Alopecia

    Alopecia is the unexpected loss of hair that leaves the skin bald. There is no antecedent or associated inflammation or symptom.

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Erysipelas

    Erysipelas is an acute cutaneous and subcutaneous inflammatory disease. It is a serious condition. If not treated properly and adequately, it can have potentially serious consequences. (Today it is known to be...

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Vertigo and Dizziness

    Vertigo is a condition that results from disturbance of the upper orifices induced by Wind, Fire, Phlegm, blood stasis or a state of deficiency. Its main symptoms are dizziness and blurring of vision. In mild ...

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Dysuria

    Dysuria is painful urination due to impedance of flow in the urethra, and is often characterized by frequency and urgency, yet dribbling of urine. Sometimes there is spasm in the lower abdomen, which may exten...

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Urinary Stones

    Stones in the urinary tract are common occurrences and are characterized by painful and difficult urination. They may form anywhere along the urinary tract, from the kidney to the urethra.

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Jaundice

    Jaundice is a common medical condition characterized by yellowing of the skin, the eyes and the urine. It results when turbid Dampness causes dysfunction of the liver, the gallbladder, the spleen and the stoma...

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Lumbago

    Lumbago is pain in the lumbar region, which is that part of the body between the lower ribs and the pelvis. The term usually refers to pain in the lumbar back or the flanks.

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Acute Lumbar Sprain

    Acute lumbar sprain is abrupt pain in the lumbar region, whether muscles, fasciae or ligaments.

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Acute Naso-Sinusitis

    Naso-sinusitis, or simply sinusitis, is nonspecific inflammation of the mucous membrane of the sinuses. The typical symptoms of acute sinusitis include fever, headache, nasal congestion and viscid or purulent ...

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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    Chapter

    Rheumatism

    Rheumatism results when genuine Qi is deficient so that Wind, Cold, Dampness, or Heat is able to invade and block the meridians, muscles and joints. This blockage impedes the flow of Qi and blood and results i...

    Zhanwen Liu in Essentials of Chinese Medicine (2010)

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