60 Result(s)

Article

Celastrol inhibits mouse B16-F10 melanoma cell survival by regulating the PI3K/AKT/mTOR signaling pathway and repressing HIF-1α expression

Melanoma, with its high degree of malignancy, stands as one of the most dangerous skin cancers and remains the primary cause of death from skin cancer. With studies demonstrating the potential of traditional C...

** Zhao, **ng-Bo He, **n-Yue Chen, Zhang-Long Li, Wen-Jia **ng… in Discover Oncology (2024)

Article

Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance

Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood.

**ang-Ning Meng, **-Fa Ma, Yang-He Liu, Si-Qing Li, Xu Wang… in British Journal of Cancer (2024)

Article

Immunophenotype of lymphocytes and real-world outcome of COVID-19 infection in children with hematology and oncology

Patients with immunocompromise were suspected to encounter a high risk for severe coronavirus disease 2019 (COVID-19) infection on early period; however, data is lacking nowadays and immune response remain unc...

Na Zhang, Zhen Wang, Hong Li, Kai Chen, Hong-sheng Wang, **g-bo Shao… in BMC Cancer (2024)

Article

A radiomics signature derived from CT imaging to predict MSI status and immunotherapy outcomes in gastric cancer: a multi-cohort study

Accurate microsatellite instability (MSI) testing is essential for identifying gastric cancer (GC) patients eligible for immunotherapy. We aimed to develop and validate a CT-based radiomics signature to predic...

Peng-chao Zhan, Shuo Yang, **ng Liu, Yu-yuan Zhang, Rui Wang, Jia-xing Wang… in BMC Cancer (2024)

Article

Author Correction: Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial

Shu-Qiang Yuan, Run-Cong Nie, Ying **, Cheng-Cai Liang, Yuan-Fang Li… in Nature Medicine (2024)

Article

Rational application of EGFR-TKI adjuvant therapy in patients with completely resected stage IB-IIIA EGFR-mutant NSCLC: a systematic review and meta-analysis of 11 randomized controlled trials

To determine the role and rational application of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) adjuvant therapy in patients with completely resected stage IB-IIIA EGFR-mutant non-small...

Shu-Ling Zhang, **ao-Fang Yi, Le-Tian Huang, Li Sun, Jie-Tao Ma, Cheng-Bo Han in BMC Cancer (2023)

Article

The pivotal application of patient-derived organoid biobanks for personalized treatment of gastrointestinal cancers

Gastrointestinal cancers (GICs) occupy more than 30% of the cancer-related incidence and mortality around the world. Despite advances in the treatment strategies, the long-term overall survival has not been im...

Ya-ya Yu, Yan-juan Zhu, Zhen-zhen **ao, Ya-dong Chen, Xue-song Chang… in Biomarker Research (2022)

Article

Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer

Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucle...

Daniel Cui Zhou, Reyka G. Jayasinghe, Siqi Chen, John M. Herndon… in Nature Genetics (2022)

Article

Burden, trends, and risk factors for breast cancer in China from 1990 to 2019 and its predictions until 2034: an up-to-date overview and comparison with those in Japan and South Korea

The difference in epidemiological characteristics of breast cancer (BC) across countries is valuable for BC management and prevention. The study evaluated the up-to-date burden, trends, and risk factors of BC ...

Na Liu, Da-Wei Yang, Yan-**a Wu, Wen-Qiong Xue, Dan-Hua Li, Jiang-Bo Zhang… in BMC Cancer (2022)

Article

Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone

Whether and how innate antiviral response is regulated by humoral metabolism remains enigmatic. We show that viral infection induces progesterone via the hypothalamic-pituitary-adrenal axis in mice. Progestero...

Shan Su, Duo Hua, **-Peng Li, **a-Nan Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

Retraction Note: Down-regulated lncRNA DLX6-AS1 inhibits tumorigenesis through STAT3 signaling pathway by suppressing CADM1 promoter methylation in liver cancer stem cells

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1239-3.

Dong-Mei Wu, Zi-Hui Zheng, Ying-Bo Zhang… in Journal of Experimental & Clinical Cancer … (2022)

Article

Step-by-step and orderly lowering of the height of inferior vena cava tumor thrombus is the key to robot-assisted thrombectomy for Mayo III/IV tumor thrombus

The surgical management of Mayo III/IV tumor thrombi is difficult and risky, and robotic surgery is even more difficult. The purpose of this study was to introduce the step-by-step and orderly lowering of the ...

Guo-Dong Zhao, **u-** Zhang, Ming-Gen Hu, Qing-Bao Huang, Shuai Xu… in BMC Cancer (2022)

Article

Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients

While some individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present mild-to-severe disease, many SARS-CoV-2-infected individuals are asymptomatic. We sought to identify the ...

**ang-Na Zhao, Yue You, **ao-Ming Cui… in Signal Transduction and Targeted Therapy (2021)

Article

Clinical option of pemetrexed-based versus paclitaxel-based first-line chemotherapeutic regimens in combination with bevacizumab for advanced non-squamous non-small-cell lung cancer and optimal maintenance therapy: evidence from a meta-analysis of randomized control trials

In the era of immunotherapy, it is still unclear which is the best first-line therapy for patients with oncogenic driver negative advanced non-squamous non-small cell lung cancer (NS-NSCLC) who cannot tolerate...

Le-Tian Huang, Rui Cao, Yan-Ru Wang, Li Sun, **ang-Yan Zhang, Yi-Jia Guo… in BMC Cancer (2021)

Article

Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome

Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne virus with high fatality and an expanding endemic. Currently, effective anti-SFTSV intervention remains unavailable. F...

Hao Li, **a-Ming Jiang, Ning Cui, Chun Yuan… in Signal Transduction and Targeted Therapy (2021)

Article

ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling

Distant metastasis is the leading cause of death for esophageal squamous cell carcinoma (ESCC) with limited treatment options and unsatisfactory effectiveness. Bromodomain (BRD) containing proteins are emergin...

Lian-**g Cao, Yi-Jun Zhang, Si-Qi Dong… in Journal of Experimental & Clinical Cancer … (2021)

Article

Short-term outcomes and safety of radiotherapy for immediate breast reconstruction with autologous flap transfer following breast-conserving surgery

The outcomes of immediate autologous breast reconstruction (IABR) after partial mastectomy followed by postoperative radiotherapy (RT) in terms of aesthetics, treatment-related complications, and local control...

Shu-Ling Zhang, Jun Song, Yan-Ru Wang, Yi-Jia Guo, Jian-Zhu Zhao, Li Sun… in BMC Cancer (2021)