52 Result(s)

Article

Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance

Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood.

**ang-Ning Meng, **-Fa Ma, Yang-He Liu, Si-Qing Li, Xu Wang… in British Journal of Cancer (2024)

Article

Immunophenotype of lymphocytes and real-world outcome of COVID-19 infection in children with hematology and oncology

Patients with immunocompromise were suspected to encounter a high risk for severe coronavirus disease 2019 (COVID-19) infection on early period; however, data is lacking nowadays and immune response remain unc...

Na Zhang, Zhen Wang, Hong Li, Kai Chen, Hong-sheng Wang, **g-bo Shao… in BMC Cancer (2024)

Article

Cervical lymph node metastasis prediction from papillary thyroid carcinoma US videos: a prospective multicenter study

Prediction of lymph node metastasis (LNM) is critical for individualized management of papillary thyroid carcinoma (PTC) patients to avoid unnecessary overtreatment as well as undesired under-treatment. Artifi...

Ming-Bo Zhang, Zhe-Ling Meng, Yi Mao, Xue Jiang, Ning Xu, Qing-Hua Xu… in BMC Medicine (2024)

Article

A radiomics signature derived from CT imaging to predict MSI status and immunotherapy outcomes in gastric cancer: a multi-cohort study

Accurate microsatellite instability (MSI) testing is essential for identifying gastric cancer (GC) patients eligible for immunotherapy. We aimed to develop and validate a CT-based radiomics signature to predic...

Peng-chao Zhan, Shuo Yang, **ng Liu, Yu-yuan Zhang, Rui Wang, Jia-xing Wang… in BMC Cancer (2024)

Article

Changes of Mycobacterium tuberculosis specific antigen-stimulated CD27⁻CD38⁺IFN-γ⁺CD4⁺ T cells before and after anti-tuberculosis treatment

The aim of the study was to investigate whether the expression of CD27⁻CD38⁺ in interferon (IFN)-γ⁺CD4⁺ T cells stimulated by the specific antigen early secreted antigenic target-6 (ESAT-6)/culture filter protein...

Yong Fang, Yuan Tang, Qiao-**a Luo, Na Wang… in European Journal of Medical Research (2024)

Article

Author Correction: Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial

Shu-Qiang Yuan, Run-Cong Nie, Ying **, Cheng-Cai Liang, Yuan-Fang Li… in Nature Medicine (2024)

Article

ANGPTL4 accelerates ovarian serous cystadenocarcinoma carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1

Ovarian cancer (OC) is a malignant neoplasm that displays increased vascularization. Angiopoietin-like 4 (ANGPTL4) is a secreted glycoprotein that functions as a regulator of cell metabolism and angiogenesis a...

Yu-kun Li, An-bo Gao, Tian Zeng, Dan Liu… in Journal of Translational Medicine (2024)

Article

Rational application of EGFR-TKI adjuvant therapy in patients with completely resected stage IB-IIIA EGFR-mutant NSCLC: a systematic review and meta-analysis of 11 randomized controlled trials

To determine the role and rational application of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) adjuvant therapy in patients with completely resected stage IB-IIIA EGFR-mutant non-small...

Shu-Ling Zhang, **ao-Fang Yi, Le-Tian Huang, Li Sun, Jie-Tao Ma, Cheng-Bo Han in BMC Cancer (2023)

Article

Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice

Genome-wide association studies (GWAS) have reported single-nucleotide polymorphisms (SNPs) in the VRK serine/threonine kinase 2 gene (VRK2) showing genome-wide significant associations with major depression, but...

Mei-Yu Yin, Lei Guo, Li-Juan Zhao, Chen Zhang, Wei-Peng Liu, Chu-Yi Zhang… in BMC Medicine (2023)

Article

Novel long noncoding RNA LINC02820 augments TNF signaling pathway to remodel cytoskeleton and potentiate metastasis in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors in China. However, there are no targets to treat ESCC because the molecular mechanism behind the cancer is still unclear. He...

**g Wang, Tie-Jun Huang, Yan Mei, Fei-Fei Luo, De-Huan **e… in Cancer Gene Therapy (2023)

Article

CpG-binding protein CFP1 promotes ovarian cancer cell proliferation by regulating BST2 transcription

Epigenetic alterations have been functionally linked to ovarian cancer development and occurrence. The CXXC zinc finger protein 1 (CFP1) is an epigenetic regulator involved in DNA methylation and histone modif...

Liu-Qing Yang, Han-Yin Hu, Yao Han, Ze-Yi Tang, Jie Gao, Qi-Yin Zhou… in Cancer Gene Therapy (2022)

Article

The pivotal application of patient-derived organoid biobanks for personalized treatment of gastrointestinal cancers

Gastrointestinal cancers (GICs) occupy more than 30% of the cancer-related incidence and mortality around the world. Despite advances in the treatment strategies, the long-term overall survival has not been im...

Ya-ya Yu, Yan-juan Zhu, Zhen-zhen **ao, Ya-dong Chen, Xue-song Chang… in Biomarker Research (2022)

Article

Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass

Birth weight is considered not only to undermine future growth, but also to induce lifelong diseases; the aim of this study is to explore the relationship between birth weight and adult bone mass.

Jiang-Wei **a, Lin Zhang, ** Li, Cheng-Da Yuan, **ao-Wei Zhu, Yu Qian… in BMC Medicine (2022)

Article

Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer

Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucle...

Daniel Cui Zhou, Reyka G. Jayasinghe, Siqi Chen, John M. Herndon… in Nature Genetics (2022)

Article

Burden, trends, and risk factors for breast cancer in China from 1990 to 2019 and its predictions until 2034: an up-to-date overview and comparison with those in Japan and South Korea

The difference in epidemiological characteristics of breast cancer (BC) across countries is valuable for BC management and prevention. The study evaluated the up-to-date burden, trends, and risk factors of BC ...

Na Liu, Da-Wei Yang, Yan-**a Wu, Wen-Qiong Xue, Dan-Hua Li, Jiang-Bo Zhang… in BMC Cancer (2022)

Article

Forkhead Box S1 mediates epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway to regulate colorectal cancer progression

Recent studies have shown that the fox family plays a vital role in tumorigenesis and progression. Forkhead Box S1 (FOXS1), as a newly identified subfamily of the FOX family, is overexpressed in certain types ...

Liang Zhang, Chuan-fu Ren, Zhi Yang, Long-bo Gong… in Journal of Translational Medicine (2022)

Article

Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke

Chronic inflammatory disorders in atrial fibrillation (AF) contribute to the onset of ischemic stroke. Systemic immune inflammation index (SIII) and system inflammation response index (SIRI) are the two novel ...

Kai-bin Lin, Feng-hua Fan, Ming-qi Cai, Yin Yu… in European Journal of Medical Research (2022)

Article

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma

HDAC inhibitors (HDACis) have been intensively studied for their roles and potential as drug targets in T-cell lymphomas and other hematologic malignancies. Bisthianostat is a novel bisthiazole-based pan-HDACi...

Yu-bo Zhou, Yang-ming Zhang, Hong-hui Huang, Li-**g Shen… in Acta Pharmacologica Sinica (2022)

Article

Inhibition of drug-metabolizing enzymes by **gyin granules: implications of herb–drug interactions in antiviral therapy

**gyin granules, a marketed antiviral herbal medicine, have been recommended for treating H1N1 influenza A virus infection and Coronavirus disease 2019 (COVID-19) in China. To fight viral diseases in a more e...

Feng Zhang, Wei Liu, Jian Huang, Qi-long Chen, Dan-dan Wang… in Acta Pharmacologica Sinica (2022)

Article

Identification of novel rheumatoid arthritis-associated MiRNA-204-5p from plasma exosomes

Rheumatoid arthritis (RA) is an autoimmune disease characterized by infiltration of immune cells in the synovium. However, the crosstalk of immune cells and synovial fibroblasts is still largely unknown. Here,...

Long-Fei Wu, Qin Zhang, **ng-Bo Mo, Jun Lin… in Experimental & Molecular Medicine (2022)