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Article
Open AccessResolvent model for aeroacoustics of trailing edge noise
This study presents a physics-based, low-order model for the trailing edge (TE) noise generated by an airfoil at low angle of attack. The approach employs incompressible resolvent analysis of the mean flow to ...
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Article
Open AccessTNFα-YAP/p65-HK2 axis mediates breast cancer cell migration
Clinical and experimental evidence indicates that macrophages could promote solid-tumor progression and metastasis. However, the mechanisms underlying this process remain unclear. Here we show that yes-associa...
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Article
Open AccessMonoacylglycerol lipase inhibitors produce pro- or antidepressant responses via hippocampal CA1 GABAergic synapses
The probability of suffering the mood disorder depression is up to 30% in women and 15% in men during their life span. Pharmacological options for depression are limited: conventional antidepressants have low ...
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Article
c-Abl–p38α signaling plays an important role in MPTP-induced neuronal death
Oxidative stress is a major cause of sporadic Parkinson’s disease (PD). Here, we demonstrated that c-Abl plays an important role in oxidative stress-induced neuronal cell death. C-Abl, a nonreceptor tyrosine k...
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Article
Open AccessCaspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner
Chemoresistance in cancer has previously been attributed to gene mutations or deficiencies. Bax or p53 deficiency can lead to resistance to cancer drugs. We aimed to find an agent to overcome chemoresistance i...
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Article
Open AccessCaspase-9 mediates Puma activation in UCN-01-induced apoptosis
The protein kinase inhibitor 7-hydroxystaurosporine (UCN-01) is one of the most potent and frequently used proapoptotic stimuli. The BH3-only molecule of Bcl-2 family proteins has been reported to contribute t...
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Article
Open AccessαNAC inhibition of the FADD-JNK axis plays anti-apoptotic role in multiple cancer cells
Nascent polypeptide-associated complex α (αNAC) is reportedly overexpressed in several types of cancers and regulates cell apoptosis under hypoxic conditions in HeLa cells. The aim of our study was to investigate...
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Article
Open AccessBlockade of inhibitors of apoptosis (IAPs) in combination with tumor-targeted delivery of tumor necrosis factor-α leads to synergistic antitumor activity
In the current study, we examined whether the combination of tumor vasculature-targeted gene therapy with adeno-associated virus bacteriophage-tumor necrosis factor-α (AAVP-TNF-α) and/or the orally administere...
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Article
Open AccessPhase I and pharmacological study of the broad-spectrum tyrosine kinase inhibitor JNJ-26483327 in patients with advanced solid tumours
JNJ-26483327 is an oral, potent, multi-targeted tyrosine kinase inhibitor, inhibiting kinases of epidermal growth factor receptor (EGFR)-1, -2 and -4, rearranged during transfection (RET) receptor, vascular en...
