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  1. No Access

    Article

    Preclinical evaluation of radiation and systemic, RGD-targeted, adeno-associated virus phage-TNF gene therapy in a mouse model of spontaneously metastatic melanoma

    The incidence of melanoma in the United States continues to rise, with metastatic lesions notoriously recalcitrant to therapy. There are limited effective treatment options available and a great need for more ...

    T J Quinn, N Healy, A Sara, E Maggi, C S Claros, R Kabarriti… in Cancer Gene Therapy (2017)

  2. No Access

    Article

    Overexpression of HOXB7 protein reduces sensitivity of oral cancer cells to chemo-radiotherapy

    The upregulation of homeobox-B7 (HOXB7) in cancers has been reported. However, its role in oral cancer progression remains to be investigated. In current study, our data revealed that reconstitution of HOXB7 e...

    Z Yuan, D Chen, X Chen, H Yang, Y Wei in Cancer Gene Therapy (2016)

  3. Article

    Open Access

    Blockade of inhibitors of apoptosis (IAPs) in combination with tumor-targeted delivery of tumor necrosis factor-α leads to synergistic antitumor activity

    In the current study, we examined whether the combination of tumor vasculature-targeted gene therapy with adeno-associated virus bacteriophage-tumor necrosis factor-α (AAVP-TNF-α) and/or the orally administere...

    Z Yuan, G Syrkin, A Adem, R Geha, J Pastoriza, C Vrikshajanani… in Cancer Gene Therapy (2013)

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  4. No Access

    Article

    Enhanced antitumor effect of cisplatin in human NSCLC cells by tumor suppressor LKB1

    LKB1 is a novel candidate tumor suppressor gene in lung cancer. In this study, we evaluated the effect of cationic liposomes (LPs)-mediated LKB1 gene (LPs-pVAX-LKB1) on low-dose cisplatin (cis-diamminedichloropla...

    W Ou, S Ye, W Yang, Y Wang, Q Ma, C Yu, H Shi, Z Yuan, G Zhong… in Cancer Gene Therapy (2012)

  5. No Access

    Article

    Liver-specific microRNA-122 target sequences incorporated in AAV vectors efficiently inhibits transgene expression in the liver

    Vectors based on adeno-associated virus (AAV) are effective in gene delivery in vivo. Tissue-specific gene expression is often needed to minimize ectopic expression in unintended cells and undesirable consequence...

    C Qiao, Z Yuan, J Li, B He, H Zheng, C Mayer, J Li, X **ao in Gene Therapy (2011)

  6. No Access

    Article

    Efficient inhibition of B-cell lymphoma xenografts with a novel recombinant fusion protein: anti-CD20Fab-LDM

    Lidamycin (LDM) is a new member of enediyne antitumor antibiotics family that can be separated and reconstituted. It consists of a labile active enediyne chromophore (AE) and a noncovalently bound apoprotein (...

    C **n, S Ye, Y Ming, Z Shenghua, M Qingfang, G Hongxing, S Xu, X Yuanfu… in Gene Therapy (2010)

  7. Article

    Open Access

    Phase I and pharmacological study of the broad-spectrum tyrosine kinase inhibitor JNJ-26483327 in patients with advanced solid tumours

    JNJ-26483327 is an oral, potent, multi-targeted tyrosine kinase inhibitor, inhibiting kinases of epidermal growth factor receptor (EGFR)-1, -2 and -4, rearranged during transfection (RET) receptor, vascular en...

    I R H M Konings, M J A de Jonge, H Burger, A van der Gaast… in British Journal of Cancer (2010)

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  8. No Access

    Article

    A muscle-targeting peptide displayed on AAV2 improves muscle tropism on systemic delivery

    Adeno-associated virus (AAV) has become a leading gene transfer vector for striated muscles. However, the AAV vectors also exhibit broad tropisms after systemic delivery. In an attempt to improve muscle tropis...

    C-Y Yu, Z Yuan, Z Cao, B Wang, C Qiao, J Li, X **ao in Gene Therapy (2009)