86 Result(s)

Article

Retinal organoids with X-linked retinoschisis RS1 (E72K) mutation exhibit a photoreceptor developmental delay and are rescued by gene augmentation therapy

X-linked juvenile retinoschisis (XLRS) is an inherited disease caused by RS1 gene mutation, which leads to retinal splitting and visual impairment. The mechanism of RS1-associated retinal degeneration is not full...

Chunwen Duan, Chengcheng Ding, **hao Sun, Shengru Mao… in Stem Cell Research & Therapy (2024)

Article

Retraction Note: CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7

Kaixuan Zeng, **aoxiang Chen, Mu Xu, **angxiang Liu, **uxiu Hu… in Cell Death & Disease (2024)

Article

Metabolism-regulated ferroptosis in cancer progression and therapy

Cancer metabolism mainly includes carbohydrate, amino acid and lipid metabolism, each of which can be reprogrammed. These processes interact with each other to adapt to the complicated microenvironment. Ferrop...

Lvlan Ye, **angqiong Wen, Jiale Qin, **ang Zhang, Youpeng Wang… in Cell Death & Disease (2024)

Article

Identification of oleic acid as an endogenous ligand of GPR3

Although GPR3 plays pivotal roles in both the nervous system and metabolic processes, such as cold-induced thermogenesis, its endogenous ligand remains elusive. Here, by combining structural approach (includin...

Yangjie **ong, Zhenmei Xu, **nzhi Li, Yuqin Wang, **g Zhao, Na Wang… in Cell Research (2024)

Article

Hsa_circ_0007990 promotes breast cancer growth via inhibiting YBX1 protein degradation to activate E2F1 transcription

Breast cancer (BC) is the most commonly diagnosed malignant tumour in females worldwide. Although remarkable advances in early detection and treatment strategies have led to decreased mortality, recurrence and...

Tao Xu, Mengqiu **ong, Qiwei Hong, Bei Pan, Mu Xu, Ying Wang… in Cell Death & Disease (2024)

Article

The clustering status of detached gastric cancer cells inhibits anoikis-induced ferroptosis to promote metastatic colonization

Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. Its role in cancer metastasis remains unclear. In this study, we aimed to investigate the potential involvement...

Juan Sun, Jie Li, Kostas Pantopoulos, Yuqin Liu, Yixuan He… in Cancer Cell International (2024)

Article

The role of ADAR1 through and beyond its editing activity in cancer

Adenosine-to-inosine (A-to-I) editing of RNA, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, is a prevalent RNA modification in mammals. It has been shown that A-to-I editing plays a critical r...

Yue Jiao, Yuqin Xu, Chengbin Liu, Rui Miao, Chunyan Liu… in Cell Communication and Signaling (2024)

Article

Ferroptosis in epithelial ovarian cancer: a burgeoning target with extraordinary therapeutic potential

Epithelial ovarian cancer (EOC) is universally acknowledged as a terrifying women killer for its high mortality. Recent research advances support that ferroptosis, an emerging iron-dependent type of regulated ...

Danhua Ruan, Jirui Wen, Fei Fang, Yuqin Lei, Zhiwei Zhao, Yali Miao in Cell Death Discovery (2023)

Article

Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases

Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration and impose a considerable economic burden on patients and society, making efforts to cure blindness imperative. Transg...

Yuqin Liang, **hao Sun, Chunwen Duan, Shibo Tang… in Stem Cell Research & Therapy (2023)

Article

Long-term survival benefit of anti-PD-1 therapy in patients with relapsed or refractory classical Hodgkin lymphoma

Anti-programmed cell death-1 (anti-PD-1) therapies have shown a favorable efficacy and good tolerance for relapsed or refractory (r/r) classical Hodgkin lymphoma (cHL). However, there are limited data on long-...

Wei** Liu, Ning**g Lin, **nqin Feng, Yan **e… in Signal Transduction and Targeted Therapy (2023)

Article

Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2

With technological advancements, radiotherapy (RT) has become an effective non-surgical treatment for hepatocellular carcinoma (HCC), comprehensively improving the local control rate of patients with HCC. Howe...

Yilin Zheng, Yizhi Zhan, Yuqin Zhang, Yaowei Zhang, Yang Liu… in Cell Death & Disease (2023)

Article

Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms

Rheumatoid arthritis (RA) is a common chronic inflammatory disorder that usually affects joints. It was found that roburic acid (RBA), an ingredient from anti-RA herb Gentiana macrophylla Pall., displayed strong ...

Na Jia, Yunzhen Gao, Min Li, Yi Liang, Yuwen Li… in Signal Transduction and Targeted Therapy (2023)

Article

CaMKIV mediates spine growth deficiency of hippocampal neurons by regulation of EGR3/BDNF signal axis in congenital hypothyroidism

Congenital hypothyroidism (CH) will cause cognitive impairment in the condition of delayed treatment. The hippocampus is one of the most affected tissues by CH, in which the functional structures of hippocampa...

Hui Wu, Guihai Suo, Tianci Li, Yuqin Zheng, Haiying Li, Feifei Shen… in Cell Death Discovery (2022)