10 Result(s)
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Article
Open AccessLoss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2
Sterol regulatory element-binding protein (SREBP)-1c is involved in cellular lipid homeostasis and cholesterol biosynthesis and is highly increased in nonalcoholic steatohepatitis (NASH). However, the molecula...
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Open AccessThrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy
Autophagy functions in cellular quality control and metabolic regulation. Dysregulation of autophagy is one of the major pathogenic factors contributing to the progression of nonalcoholic fatty liver disease (...
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Article
Open AccessMitochondria-associated programmed cell death as a therapeutic target for age-related disease
Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate. Evidence has shown mitochon...
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Article
Open AccessLY6D is crucial for lipid accumulation and inflammation in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a serious metabolic disorder characterized by excess fat accumulation in the liver. Over the past decade, NAFLD prevalence and incidence have risen globally. There a...
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Open AccessMitoribosome insufficiency in β cells is associated with type 2 diabetes-like islet failure
Genetic variations in mitoribosomal subunits and mitochondrial transcription factors are related to type 2 diabetes. However, the role of islet mitoribosomes in the development of type 2 diabetes has not been ...
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Open AccessInducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection
Vascular smooth muscle cells (VSMCs) have remarkable plasticity in response to diverse environmental cues. Although these cells are versatile, chronic stress can trigger VSMC dysfunction, which ultimately lead...
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Article
Open AccessLactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells
To evaluate the immunomodulatory effect of Lactobacillus sakei in a mouse model of rheumatoid arthritis (RA) and in human immune cells.
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Article
Effects of Age, Gender and Level of Co-contraction on Elbow and Shoulder Rotational Stiffness and Dam** in the Impulsively End-Loaded Upper Extremity
Whether an arm will buckle under an impulsive end-load should partly depend on the elastic and viscous properties of the pretensed arm muscles. In measuring these properties we hypothesized that neither age, g...
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Article
Age and Gender Effects on the Proximal Propagation of an Impulsive Force Along the Adult Human Upper Extremity
We tested the null hypotheses that neither age, gender nor muscle pre-cocontraction state affect the latencies of changes in upper extremity kinematics or elbow muscle activity following an impulsive force to ...
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Article
The Effects of Gender, Level of Co-Contraction, and Initial Angle on Elbow Extensor Muscle Stiffness and Dam** Under a Step Increase in Elbow Flexion Moment
Flexion buckling of an arm under the large ground reaction loads associated with arresting a fall to the ground increases the risk for head and thorax injuries. Yet, the factors that determine the arm buckling...
