16 Result(s)
within
Yunju **ao
Biomedicine
English
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Article
Open AccessLoss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2
Sterol regulatory element-binding protein (SREBP)-1c is involved in cellular lipid homeostasis and cholesterol biosynthesis and is highly increased in nonalcoholic steatohepatitis (NASH). However, the molecula...
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Open AccessEfficacy and Safety of Candidate Biosimilar CT-P43 Versus Originator Ustekinumab in Moderate to Severe Plaque Psoriasis: 28-Week Results of a Randomised, Active-Controlled, Double-Blind, Phase III Study
CT-P43 is a candidate ustekinumab biosimilar in clinical development.
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Open AccessA CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity
Immunotherapy has significantly advanced cancer treatments, but many patients do not respond to it, partly due to immunosuppressive mechanisms used by tumor cells. These cells employ immunosuppressive ligands ...
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Open AccessThrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy
Autophagy functions in cellular quality control and metabolic regulation. Dysregulation of autophagy is one of the major pathogenic factors contributing to the progression of nonalcoholic fatty liver disease (...
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Open AccessMitochondria-associated programmed cell death as a therapeutic target for age-related disease
Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate. Evidence has shown mitochon...
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Open AccessLY6D is crucial for lipid accumulation and inflammation in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a serious metabolic disorder characterized by excess fat accumulation in the liver. Over the past decade, NAFLD prevalence and incidence have risen globally. There a...
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Open AccessMitoribosome insufficiency in β cells is associated with type 2 diabetes-like islet failure
Genetic variations in mitoribosomal subunits and mitochondrial transcription factors are related to type 2 diabetes. However, the role of islet mitoribosomes in the development of type 2 diabetes has not been ...
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Open AccessInducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection
Vascular smooth muscle cells (VSMCs) have remarkable plasticity in response to diverse environmental cues. Although these cells are versatile, chronic stress can trigger VSMC dysfunction, which ultimately lead...
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Article
Open AccessLactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells
To evaluate the immunomodulatory effect of Lactobacillus sakei in a mouse model of rheumatoid arthritis (RA) and in human immune cells.
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Article
Role of a single session of ball throwing exercise on postural control in older adults with mild cognitive impairment
The purpose of the study was to investigate the role of training in improvement of balance control in older adults with mild cognitive impairment.
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Article
Effect of a cognitive task and light finger touch on standing balance in healthy adults
The purpose of the study was to investigate the individual and combined effects of applying light finger touch and performing a cognitive task on postural sway. Fourteen healthy young individuals stood on the ...
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Effects of Age, Gender and Level of Co-contraction on Elbow and Shoulder Rotational Stiffness and Dam** in the Impulsively End-Loaded Upper Extremity
Whether an arm will buckle under an impulsive end-load should partly depend on the elastic and viscous properties of the pretensed arm muscles. In measuring these properties we hypothesized that neither age, g...
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Age and Gender Effects on the Proximal Propagation of an Impulsive Force Along the Adult Human Upper Extremity
We tested the null hypotheses that neither age, gender nor muscle pre-cocontraction state affect the latencies of changes in upper extremity kinematics or elbow muscle activity following an impulsive force to ...
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Article
Open AccessHistotype-specific copy-number alterations in ovarian cancer
Epithelial ovarian cancer is characterized by multiple genomic alterations; most are passenger alterations which do not confer tumor growth. Like many cancers, it is a heterogeneous disease and can be broadly ...
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The Effects of Gender, Level of Co-Contraction, and Initial Angle on Elbow Extensor Muscle Stiffness and Dam** Under a Step Increase in Elbow Flexion Moment
Flexion buckling of an arm under the large ground reaction loads associated with arresting a fall to the ground increases the risk for head and thorax injuries. Yet, the factors that determine the arm buckling...
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Article
Involvement of the GP63 protease in infection of Trichomonas vaginalis
There are 48 members of the GP63 protease family in Trichomonas vaginalis according to our annotations; 37 of them are predicted to be transmembrane proteins. Because the GP63 protease family is the largest surfa...
