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Article
Open AccessWhen will the Glomerular Filtration Rate in Former Preterm Neonates Catch up with Their Term Peers?
Whether and when glomerular filtration rate (GFR) in preterms catches up with term peers is unknown. This study aims to develop a GFR maturation model for (pre)term-born individuals from birth to 18 years of a...
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Article
Open AccessMaturation of Paracetamol Elimination Routes in Preterm Neonates Born Below 32 Weeks of Gestation
Despite being off-label, intravenous paracetamol (PCM) is increasingly used to control mild-to-moderate pain in preterm neonates. Here we aim to quantify the maturation of paracetamol elimination pathways in p...
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Article
Open AccessGenomic characterization of an Omono River virus isolated from Culex tritaeniorhynchus in eastern China
Omono River virus (OMRV) is a newly reported, unclassified RNA virus in the family Totiviridae, which infects mosquitoes and bats. In this study, we report the isolation of an OMRV strain SD76 from Culex tritaeni...
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Article
Open AccessPre- and Postnatal Maturation are Important for Fentanyl Exposure in Preterm and Term Newborns: A Pooled Population Pharmacokinetic Study
Fentanyl is an opioid commonly used to prevent and treat severe pain in neonates; however, its use is off label and mostly based on bodyweight. Given the limited pharmacokinetic information across the entire n...
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Article
Open AccessPrediction of glomerular filtration rate maturation across preterm and term neonates and young infants using inulin as marker
Describing glomerular filtration rate (GFR) maturation across the heterogeneous population of preterm and term neonates and infants is important to predict the clearance of renally cleared drugs. This study ai...
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Article
Open AccessBusulfan systemic exposure and its relationship with efficacy and safety in hematopoietic stem cell transplantation in children: a meta-analysis
Busulfan (Bu) is a key component of several conditioning regimens used before hematopoietic stem cell transplantation (HSCT). However, the optimum systemic exposure (expressed as the area under the concentrati...
