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Open AccessThe dissolved organic matter from the co-decomposition of Chinese milk vetch and rice straw induces the strengthening of Cd remediation by Fe-modified biochar
Fe-modified biochar (FB) and co-using Chinese milk vetch and rice straw (MR) are two effective ways for mitigating the cadmium (Cd) contamination in paddy fields in southern China. Nevertheless, the effects of...
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Article
Open AccessAllograft Model of Aortic Arch Segment Grafting to Abdominal Aorta Through End-to-Side Anastomosis in Mice
The mouse aortic transplantation model is a valuable tool for investigating the mechanisms of atherosclerosis regression, but few laboratories can generate it due to the operation difficulty, especially for th...
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Article
Pregnancy-induced physiological hypertrophic preconditioning attenuates pathological myocardial hypertrophy by activation of FoxO3a
Previous studies show a woman’s pregnancy is correlated with post-reproductive longevity, and nulliparity is associated with higher risk of incident heart failure, suggesting pregnancy likely exerts a cardiopr...
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Article
Open AccessDelayed PCI is not beneficial for STEMI patients with impaired renal function: a retrospective cohort study
Preexisting impaired renal function (IRF) and contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) are important...
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Article
Effects of substitution of chemical fertilizer by Chinese milk vetch on distribution and composition of aggregates-associated organic carbon fractions in paddy soils
Green manure plays a key role in reducing chemical fertilizer applications and increasing soil organic carbon (SOC) stock. The effects of chemical fertilizer substitution by Chinese milk vetch (MV) on the dist...
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Article
Open AccessCharacteristics and significance of peripheral blood T-cell receptor repertoire features in patients with indeterminate lung nodules
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Article
Nitrogen application practices to reduce cadmium concentration in rice (Oryza sativa L.) grains
Cadmium (Cd) pollution in paddy soils creates challenges in rice grain production, thereby threatening food security. The effectiveness of different base-tillering-panicle urea application ratios and the combi...
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Article
Soil bacterial communities interact with silicon fraction transformation and promote rice yield after long-term straw return
Returning crop straw into the soil is an important practice to balance biogenic and bioavailable silicon (Si) pool in paddy, which is crucial for the healthy growth of rice. However, owing to little knowledge ...
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Article
Open AccessSingle-cell analysis of a tumor-derived exosome signature correlates with prognosis and immunotherapy response
Tumor-derived exosomes (TEXs) are involved in tumor progression and the immune modulation process and mediate intercellular communication in the tumor microenvironment. Although exosomes are considered promisi...
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Article
Open AccessCRIP1 cooperates with BRCA2 to drive the nuclear enrichment of RAD51 and to facilitate homologous repair upon DNA damage induced by chemotherapy
Homologous recombination (HR) repair is an important determinant of chemosensitivity. However, the mechanisms underlying HR regulation remain largely unknown. Cysteine-rich intestinal protein 1 (CRIP1) is a me...
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Article
Open AccessDifferences in the clinical presentation, management, and in-hospital outcomes of acute aortic dissection in patients with and without end-stage renal disease
Few studies have evaluated the clinical presentation, management, and outcomes of patients with end-stage renal disease (ESRD) presenting with acute aortic dissection (AAD) in real-world clinical practice. Thu...
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Article
Open AccessGrowth differentiation factor 11 attenuates cardiac ischemia reperfusion injury via enhancing mitochondrial biogenesis and telomerase activity
It has been reported that growth differentiation factor 11 (GDF11) protects against myocardial ischemia/reperfusion (IR) injury, but the underlying mechanisms have not been fully clarified. Considering that GD...
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Open AccessSubstituting chemical P fertilizer with organic manure: effects on double-rice yield, phosphorus use efficiency and balance in subtropical China
Organic manure is an ideal alternative fertilizer to provide phosphorus (P) but is not fully recycled in subtropical China. In order to identify if it can replace chemical P fertilizer, a 35-year field trail i...
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Open AccessLoss of FoxO3a prevents aortic aneurysm formation through maintenance of VSMC homeostasis
Vascular smooth muscle cell (VSMC) phenotypic switching plays a critical role in the formation of abdominal aortic aneurysms (AAAs). FoxO3a is a key suppressor of VSMC homeostasis. We found that in human and a...
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Open AccessThe geriatric nutrition risk index versus the mini-nutritional assessment short form in predicting postoperative delirium and hospital length of stay among older non-cardiac surgical patients: a prospective cohort study
Malnutrition has been shown to be associated with poor prognosis in older surgical patients. Several tools are available for detecting malnutrition. But little is known about their ability to assess risks of p...
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Open AccessImmune cell infiltration as a biomarker for the diagnosis and prognosis of stage I–III colon cancer
Tumour-infiltrating immune cells are a source of important prognostic information for patients with resectable colon cancer. We developed a novel immune model based on systematic assessments of the immune land...
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Open AccessATXN2L upregulated by epidermal growth factor promotes gastric cancer cell invasiveness and oxaliplatin resistance
For gastric cancer (GC) control, metastasis and chemoresistance are the major challenges, accompanied with various stresses. Ataxin-2-like (ATXN2L) was discovered as a novel regulator of stress granules, yet i...
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Article
Open AccessThe effects of ultrasound exposure on P-glycoprotein-mediated multidrug resistance in vitro and in vivo
Multidrug resistance (MDR) is often responsible for the failure of chemotherapy treatment, and current strategies for cancer MDR are not adequately satisfying as to their efficacy and safety. In this study, we...
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Open AccessAn essential role for Wnt/β-catenin signaling in mediating hypertensive heart disease
Activation of the renin-angiotensin system (RAS) is associated with hypertension and heart disease. However, how RAS activation causes cardiac lesions remains elusive. Here we report the involvement of Wnt/β-c...
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Comparison of Magnetic Microbubbles and Dual-modified Microbubbles Targeted to P-selectin for Imaging of Acute Endothelial Inflammation in the Abdominal Aorta
Ultrasound molecular imaging (UMI) has potential to evaluate an inflammatory profile of endothelium. However, it is less successful in large arteries. This study compared magnetic microbubbles (MBs) selectivel...