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Article
Simulation study on penetration depth of light in the source–detector distance using a nine-layered skin tissue model in the visible wavelength range
We simulated the relationship between the diffuse reflectance and penetration depth of light in skin with respect to the source (S)–detector (D) distance using the nine-layered skin tissue model for three wave...
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Article
Diffuse optical tomography: Present status and its future
Diffuse optical tomography (DOT) is one of the emerging modalities for the non-invasive imaging of thick biological tissues using near-infrared (NIR) light. This article reviews the fundamentals and developmen...
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Article
Effects of spatial variation of skull and cerebrospinal fluid layers on optical map** of brain activities
In order to investigate the effects of anatomical variation in human heads on the optical map** of brain activity, we perform simulations of optical map** by solving the photon diffusion equation for layer...
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Article
Light propagation for time-domain fluorescence diffuse optical tomography by convolution using lifetime function
Time-domain light propagation in biological tissue is studied by solving the forward problem for fluorescence diffuse optical tomography using a convolution of the zero-lifetime emission light and the exponent...
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Article
Monte Carlo Simulation of Near Infrared Reflectance Spectroscopy in the Wavelength Range from 1000 nm to 1900 nm
We have calculated the characteristics of reflected near infrared light, which is incident on the skin surface, scattered in the skin tissue and detected, in the wavelength range from 1000 nm to 1900 nm. We ha...
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Article
Fundamental Study of Reflection Pulse Oximetry
For the purpose of develo** reflection pulse oximetry, we have analyzed the light propagation in tissue to calculate the photon-visit depth for reflected light and to estimate the measured intensities of tra...
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Article
Instrumental Requirements for Non-Invasive Blood Glucose Measurement Using NIR Spectroscopy
The magnitude of spectral change in blood glucose measurements with diffuse reflectance spectroscopy is investigated. Spectral change is estimated by simulation of light propagation in skin tissue and measurem...
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Article
Temperature-Insensitive Measurement of Glucose Concentration Based on Near Infrared Spectroscopy and Partial Least Squares Analysis
Temperature-insensitive partial least squares analysis for glucose measurement is presented based on Near Infrared spectroscopy in the wavelength range from 1,250 to 1,800nm. Experiments are performed using aq...
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Article
Time-Resolved Measurements of in vivo Optical Properties of Piglet Brain
The in vivo optical properties of a piglet brain were measured using a time-resolved system at three different wavelengths (759, 794, 824 nm). To separate the contribution of different head layers to the detected...
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Article
Fundamental Studies of Photon Migration in Biological Tissues and Their Application to Optical Tomography
This paper reviews the studies of photon migration in biological tissues and its application to optical tomography which were conducted in the Mechanical Engineering Laboratory of Japan’s Ministry of Internati...
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Article
Explanation of Human Skin Color by Multiple Linear Regression Analysis Based on the Modified Lambert-Beer Law
Quantitative analysis of human skin color is needed in the medical and cosmetic fields. Because of the strong light scattering by biological tissues, however, analysis of skin color has not yet been fully succ...
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Article
Determination of the Asymmetry Parameter and Scattering Coefficient of Turbid Media from Spatially Resolved Reflectance Measurements
We present a technique for determining the asymmetry parameter and scattering coefficient of turbid media from spatially resolved reflectance measurements. This technique will contribute to the development of ...
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Article
Frequency-Domain Measurements of Diffusing Photon Propagation in Solid Phantoms
Photon propagation in a highly scattering medium such as living tissue is well described by the photon diffusion equation. In a homogeneous and isotropic case, the equation has analytically been solved for a m...
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Article
Absorption Coefficient Measurements of Strongly Scattering Media Using Time-Resolved Transmittance of a Short Pulse in Near-Infrared (NIR) Wavelength Range
Absorption coefficient measurements of strongly scattering and weakly absorbing media have been performed using time resolved transmittance of a 100 fs pulse through a 30 mm slab containing latex spheres suspe...