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Article
Open AccessDevelopment of flavivirus subviral particles with low cross-reactivity by mutations of a distinct antigenic domain
The most conserved fusion loop (FL) domain present in the flavivirus envelope protein has been reported as a dominant epitope for cross-reactive antibodies to mosquito-borne flaviviruses (MBFVs). As a result, ...
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Article
Open AccessVirological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants
In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two...
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Article
Open AccessConvergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant
In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These variants convergently acquired amino acid substitutions at critical residues in the spike protein, including residues R346, K...
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Article
Open AccessA novel nairovirus associated with acute febrile illness in Hokkaido, Japan
The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairoviru...
