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Article
Prediction of tissue origin of adenocarcinomas in the esophagogastric junction by DNA methylation
Prediction of tissue origin of esophagogastric junction (EGJ) adenocarcinomas can be important for therapeutic decision, but no molecular marker is available. Here, we aimed to develop such a marker taking adv...
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Article
Autoimmune gastritis induces aberrant DNA methylation reflecting its carcinogenic potential
Autoimmune gastritis (AIG) is a chronic inflammatory condition in gastric mucosa and is associated with increased cancer risk, though not as high as that by Helicobacter pylori (H. pylori)-associated gastritis (H...
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Article
The methylation level of a single cancer risk marker gene reflects methylation burden in gastric mucosa
Gastric cancer risk can be accurately predicted by measuring the methylation level of a single marker gene in gastric mucosa. However, the mechanism is still uncertain. We hypothesized that the methylation lev...
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Article
Open AccessMarked intestinal trans-differentiation by autoimmune gastritis along with ectopic pancreatic and pulmonary trans-differentiation
Autoimmune gastritis (AIG) is a prevalent chronic inflammatory disease with oncogenic potential that causes destruction of parietal cells and severe mucosal atrophy. We aimed to explore the distinctive gene ex...