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  1. Article

    Prediction of tissue origin of adenocarcinomas in the esophagogastric junction by DNA methylation

    Prediction of tissue origin of esophagogastric junction (EGJ) adenocarcinomas can be important for therapeutic decision, but no molecular marker is available. Here, we aimed to develop such a marker taking adv...

    Chun-Dong Zhang, Hideyuki Takeshima, Shigeki Sekine, Satoshi Yamashita in Gastric Cancer (2022)

  2. No Access

    Article

    Autoimmune gastritis induces aberrant DNA methylation reflecting its carcinogenic potential

    Autoimmune gastritis (AIG) is a chronic inflammatory condition in gastric mucosa and is associated with increased cancer risk, though not as high as that by Helicobacter pylori (H. pylori)-associated gastritis (H...

    Chihiro Takeuchi, Junichi Sato, Satoshi Yamashita in Journal of Gastroenterology (2022)

  3. Article

    The methylation level of a single cancer risk marker gene reflects methylation burden in gastric mucosa

    Gastric cancer risk can be accurately predicted by measuring the methylation level of a single marker gene in gastric mucosa. However, the mechanism is still uncertain. We hypothesized that the methylation lev...

    Takahiro Irie, Harumi Yamada, Chihiro Takeuchi, Yu-Yu Liu in Gastric Cancer (2023)

  4. Article

    Open Access

    Marked intestinal trans-differentiation by autoimmune gastritis along with ectopic pancreatic and pulmonary trans-differentiation

    Autoimmune gastritis (AIG) is a prevalent chronic inflammatory disease with oncogenic potential that causes destruction of parietal cells and severe mucosal atrophy. We aimed to explore the distinctive gene ex...

    Chihiro Takeuchi, Junichi Sato, Nobutake Yamamichi in Journal of Gastroenterology (2024)