231 Result(s)
within
Yu-**n Gao
Life Sciences
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Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Coordinated action of a gut–liver pathway drives alcohol detoxification and consumption
Alcohol use disorder (AUD) affects millions of people worldwide, causing extensive morbidity and mortality with limited pharmacological treatments. The liver is considered as the principal site for the detoxif...
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Article
Synthesis, Structure, and Antitumor Activities of Dehydroepiandrosteronyl Derivatives with 1,2,3-Triazoles
Objective: Dehydroepiandrosterone plays an important role in the human beings due to its ability to be converted into androgens and oestrogens. The aim of this paper is to synthesize a series of novel dehydroepia...
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Isolation, identification, and tolerance analysis of yeast during the natural fermentation process of Sidamo coffee beans
Yeast, which plays a pivotal role in the brewing, food, and medical industries, exhibits a close relationship with human beings. In this study, we isolated and purified 60 yeast strains from the natural fermen...
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Open AccessSpatial transcriptomics reveals gene interactions and signaling pathway dynamics in rat embryos with anorectal malformation
Anorectal malformation (ARM) is a prevalent early pregnancy digestive tract anomaly. The intricate anatomy of the embryonic cloaca region makes it challenging for traditional high-throughput sequencing methods...
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Environmental Flow Increases The Riparian Vegetation Diversity And Community Similarity
Environmental flow is increasingly used in restoring degraded riparian vegetation. To assess the impact of environmental flow on plant community characteristics and to provide a scientif...
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Article
Open AccessAn unexpected role of EasDaf: catalyzing the conversion of chanoclavine aldehyde to chanoclavine acid
Ergot alkaloids (EAs) are a diverse group of indole alkaloids known for their complex structures, significant pharmacological effects, and toxicity to plants. The biosynthesis of these compounds begins with ch...
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Article
A functional study reveals CsNAC086 regulated the biosynthesis of flavonols in Camellia sinensis
CsNAC086 was found to promote the expression of CsFLS, thus promoting the accumulation of flavonols in Camellia sinensis.
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Proteomics Sequencing Reveals the Role of TGF-β Signaling Pathway in the Peripheral Blood of Offspring Rats Exposed to Fluoride
The underlying mechanism of fluorosis has not been fully elucidated. The purpose of this study was to explore the mechanism of fluorosis induced by sodium fluoride (NaF) using proteomics. Six offspring rats ex...
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Article
Reactive oxygen species (ROS) modulate nitrogen signaling using temporal transcriptome analysis in foxtail millet
Reactive oxygen species (ROS) is a chemically reactive chemical substance containing oxygen and a natural by-product of normal oxygen metabolism. Excessive ROS affect the growth process of crops, which will le...
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Investigation of the mutual crosstalk between ER stress and PI3K/AKT/mTOR signaling pathway in iron overload-induced liver injury in chicks
Iron is an essential element for the normal functioning of living organisms, but excessive iron deposition can lead to organ damage. This study aims to investigate the interaction between the endoplasmic retic...
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Investigation on screening, identification, and fermentation characteristics of Yunnan olive in the fermented liquid utilizing five strains of Saccharomyces cerevisiae
Refined indigenous Saccharomyces cerevisiae can enhance refinement, sophistication, and subtlety of fruit wines by showcasing exceptional regional characteristics. In order to identify exceptional indigenous S. c...
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Open AccessSingle-cell transcriptome reveals a novel mechanism of C-Kit+-liver sinusoidal endothelial cells in NASH
To understand how liver sinusoidal endothelial cells (LSECs) respond to nonalcoholic steatohepatitis (NASH).
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Article
Open AccessThe potential role of hydrogen sulfide in cancer cell apoptosis
For a long time, hydrogen sulfide (H2S) has been considered a toxic compound, but recent studies have found that H2S is the third gaseous signaling molecule which plays a vital role in physiological and pathologi...
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Genomic study of PIFs in cotton and functional analysis of GhPIF4 in promoting cotton flowering
Cotton is the most important commercial crop in the production of fiber for the textile industry worldwide, and flowering time is an important agronomic trait for cotton production. Phytochrome interacting fac...
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Article
Endothelial extracellular vesicles induce acute lung injury via follistatin-like protein 1
Cardiopulmonary bypass has been speculated to elicit systemic inflammation to initiate acute lung injury (ALI), including acute respiratory distress syndrome (ARDS), in patients after cardiac surgery. We previ...
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Heterozygosity analysis of spontaneous 2n female gametes and centromere map** of the diploid Hevea brasiliensis based on full-sib triploid populations
Unreduced megagametophytes via second-division restitution were confirmed through heterozygosity analysis, and four candidate physical centromeres of rubber were located for the first time.
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Article
Psychromicrobium **ongbiense sp. nov., an Actinobacterium Isolated from Forest Soil
A novel Gram-stain-positive, oval-shaped, and non-flagellated bacterial strain YIM S02556T was isolated from forest soil in **ongbi Town, Shizong County, Qu**g City, Yunnan Province, southwestern China. The stra...
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Open AccessSingle-cell transcriptome analyses reveal critical regulators of spermatogonial stem cell fate transitions
Spermatogonial stem cells (SSCs) are the foundation cells for continual spermatogenesis and germline regeneration in mammals. SSC activities reside in the undifferentiated spermatogonial population, and curren...
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Human Bone Marrow Derived-Mesenchymal Stem Cells Treatment for Autoimmune Premature Ovarian Insufficiency
Premature ovarian insufficiency (POI) is a relatively common gynecologic endocrine disorder, which is hypogonadism associated with amenorrhea, increased levels of gonadotropins, and hypoestrogenism. POI result...
