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Article
Preparation of thermo-responsive and injectable hydrogels based on hyaluronic acid and poly(N-isopropylacrylamide) and their drug release behaviors
Copolymers composed of hyaluronic acid (HA) and poly(N-isopropylacrylamide) (PNIPAAm) were prepared to create temperature-sensitive injectable gels for use in controlled drug delivery applications. Semi-telecheli...
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Article
Linear low density polyethylene (LLDPE)/zeolite microporous composite film
The linear low density polyethylene (LLDPE)/zeolite composite using novel inorganic filler, zeolite, is prepared by a conventional compounding procedure using a twin-screw extruder. The observed scanning elect...
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Article
Simple purification ofEscherichia coli-derived recombinant human interleukin-2 expressed with N-terminus fusion of glucagon
Simple procedures have been devised for purifying recombinant human interleukin-2 (hIL-2), which was expressed inEscherichia coli using sequences of glucagon molecules and enterokinase cleavage site as an N-termi...
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Article
Production of lyophilized culture ofLactobacillus acidophilus with preserving cell viability
Optimal lyophilization process was developed for manufacturing the dried product ofLactobacillus acidophilus with high cell viability. Three major factors, freezing rate, specific surface area of samples, and sta...
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Article
Application of genetic algorithm to self-organizing fuzzy controller in fed-batch culture ofScutellaria baicalensis G. plant cell
A self-organizing fuzzy controller is constructed for control of substrate concentration in fed-batch operation of a cell culture process. A genetic algorithm is used to generate fuzzy rules of the self-organi...
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Article
Effects of medium components on L-ornithine production byBrevibacterium ketoglutamicum
Effects of yeast extract, and ammonium sulfate were investigated on the production of L-ornithine by an arginine auxotroph.Brevibacterium ketoglutamicum in flask and batch cultures. Yeast extract as an arginine s...
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Chapter and Conference Paper
Flavonoid Production from a Cell Suspension Culture of Scutellaria Baicalensis G
Scutellaria baicalensis G. is a perennial plant belonging to the Labiatae [1]. Its three or four year old root has been used as a medical herb effective to disease such as inflammation, pyrexia and congestion [2]...
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Chapter and Conference Paper
Computer-Controlled Fed-Batch Cultivation of a Recombinant Escherichia coli for Overproduction of Human Interleukin-2
To determine the optimal feeding policy in fed-batch fermentation, a variety of problem-specific methods have been proposed in recent years. A problem closely related to the glucose feeding policy is the excre...
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Article
Production of recombinant human interleukin-z by Escherichia coli with computer controlled temperature induction
The amount of alkali added to the fermentation broth of a recombinant Escherichia coli strain for pH control was monitored on-line by an electronic balance interfaced to a computer. It was successfully correlated...