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    Article

    A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells

    Natural compound valepotriate exhibits inhibitory activity against a number of cancers, but the effect of valepotriate against pancreatic cancer is unclear, and the structure–activity relationship of valepotri...

    You-you Yan, Ke-yu Shi, Fei Teng, **g Chen, **-xin Che in Acta Pharmacologica Sinica (2020)

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    Open Access

    Deacetylisovaltratum disrupts microtubule dynamics and causes G2/M-phase arrest in human gastric cancer cells in vitro

    Deacetylisovaltratum (DI) is isolated from the traditional Chinese herbal medicine Patrinia heterophylla Bunge, which exhibits anti-cancer activity. Here, we investigated the effects of DI on human gastric carcin...

    Dan Zhang, Bo Zhang, Li-xin Zhou, Jun Zhao, You-you Yan in Acta Pharmacologica Sinica (2016)