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  1. No Access

    Article

    Higher Plasma Osteopontin Concentrations Associated with Subsequent Development of Chronic Shunt-Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage

    A matricellular protein osteopontin (OPN) is considered to exert neuroprotective and healing effects on neurovascular injuries in an acute phase of aneurysmal subarachnoid hemorrhage (SAH). However, the relati...

    Reona Asada, Yoshinari Nakatsuka, Hideki Kanamaru… in Translational Stroke Research (2021)

  2. No Access

    Article

    Machine Learning Analysis of Matricellular Proteins and Clinical Variables for Early Prediction of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage

    Although delayed cerebral ischemia (DCI) is a well-known complication after subarachnoid hemorrhage (SAH), there are no reliable biomarkers to predict DCI development. Matricellular proteins (MCPs) have been r...

    Satoru Tanioka, Fujimaro Ishida, Fumi Nakano, Fumihiro Kawakita… in Molecular Neurobiology (2019)

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    Article

    Dose-Dependent Inhibitory Effects of Cilostazol on Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage

    Cilostazol is a selective inhibitor of phosphodiesterase type III that downregulates tenascin-C (TNC), a matricellular protein, which may cause delayed cerebral infarction after aneurysmal subarachnoid hemorrh...

    Hidenori Suzuki, Yoshinari Nakatsuka, Ryuta Yasuda… in Translational Stroke Research (2019)

  4. No Access

    Article

    Anti-vasospastic Effects of Epidermal Growth Factor Receptor Inhibitors After Subarachnoid Hemorrhage in Mice

    Subarachnoid hemorrhage (SAH) is a devastating disease. Cerebral vasospasm is still an important cause of post-SAH poor outcomes, but its mechanisms remain unveiled. Activation of epidermal growth factor recep...

    Fumi Nakano, Fumihiro Kawakita, Lei Liu, Yoshinari Nakatsuka… in Molecular Neurobiology (2019)

  5. No Access

    Article

    Acute-Phase Plasma Osteopontin as an Independent Predictor for Poor Outcome After Aneurysmal Subarachnoid Hemorrhage

    Experimental studies reported that osteopontin (OPN), a matricellular protein, is induced in brain after subarachnoid hemorrhage (SAH). The aim of this study was to investigate the relationships between plasma...

    Yoshinari Nakatsuka, Masato Shiba, Hirofumi Nishikawa… in Molecular Neurobiology (2018)

  6. No Access

    Article

    Increased Plasma Galectin-3 Preceding the Development of Delayed Cerebral Infarction and Eventual Poor Outcome in Non-Severe Aneurysmal Subarachnoid Hemorrhage

    A matricellular protein galectin-3 is involved in tissue injury and inflammation, but the role of galectin-3 remains unclear in aneurysmal subarachnoid hemorrhage (SAH). The purpose of this study was to assess...

    Hirofumi Nishikawa, Yoshinari Nakatsuka, Masato Shiba… in Translational Stroke Research (2018)

  7. No Access

    Article

    Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice

    Toll-like receptor 4 (TLR4) signaling may play a crucial role in the occurrence of cerebral vasospasm after subarachnoid hemorrhage (SAH). The main purpose of this study was to assess if selective blockage of ...

    Fumihiro Kawakita, Masashi Fujimoto, Lei Liu, Fumi Nakano… in Molecular Neurobiology (2017)

  8. No Access

    Article

    Higher Cerebrospinal Fluid pH may Contribute to the Development of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

    Recent investigations have shown that many factors may cause delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH). To find new potential contributors to DCI, this retrospective study ...

    Hidenori Suzuki, Masato Shiba, Yoshinari Nakatsuka… in Translational Stroke Research (2017)