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  1. Article

    Open Access

    A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway

    Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer with high aggressive phenotype and poor prognosis. Accumulating evidence suggests that circRNAs have been identified as pivotal media...

    Bo Huang, Junwu Ren, Qiang Ma, Feifei Yang, **aojuan Pan, Yuying Zhang… in Molecular Cancer (2024)

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  2. Article

    Open Access

    Spatial heterogeneity of tumor microenvironment influences the prognosis of clear cell renal cell carcinoma

    Clear cell renal cell carcinoma (ccRCC) is an immunologically and histologically diverse tumor. However, how the structural heterogeneity of tumor microenvironment (TME) affects cancer progression and treatmen...

    Dawei Zhang, Yuanli Ni, Yongquan Wang, Juan Feng… in Journal of Translational Medicine (2023)

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  3. Article

    Open Access

    Genomic and transcriptomic features between primary and paired metastatic fumarate hydratase–deficient renal cell carcinoma

    Fumarate hydratase–deficient renal cell carcinoma (FH-RCC) is a rare highly aggressive subtype of kidney cancer for which the distinct genomic, transcriptomic, and evolutionary relationships between metastatic...

    Jiayu Liang, Guangxi Sun, **uyi Pan, Mengni Zhang, Pengfei Shen, Sha Zhu… in Genome Medicine (2023)

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