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CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke

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  1. Article

    Open Access

    RIPK1 inhibition contributes to lysosomal membrane stabilization in ischemic astrocytes via a lysosomal Hsp70.1B-dependent mechanism

    Receptor-interacting protein kinase 1 (RIPK1) contributes to necroptosis. Our previous study showed that pharmacological or genetic inhibition of RIPK1 protects against ischemic stroke-induced astrocyte injury...

    Hua-** Du, Yi Guo, Yong-ming Zhu, De-fei Gao, Bo Lin… in Acta Pharmacologica Sinica (2023)

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  2. Article

    Autophagy and cathepsin L are involved in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model

    2-(3′,5′-Dimethoxybenzylidene) cyclopentanone (DMBC) is a novel synthetic compound with antinociceptive activities. The aim of this study was to investigate the roles of the autophagic-lysosomal pathway in the...

    Wei-wei Gu, Gui-zhen Ao, Yong-ming Zhu, Shi-chang Sun… in Acta Pharmacologica Sinica (2013)

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