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    Open Access

    IP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway

    Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca2+) has been associated with cardiomyocyte pyroptosis. Specifically, the inositol 1,4,5-trisphosphate receptor type 2 (IP...

    Qing-Rui Wu, Hui Yang, Hui-Dan Zhang, Yong-Jiang Cai… in Cell Death Discovery (2024)

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