4 Result(s)
within
Yong-Hui Zheng
Cancer Research
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Article
Open AccessHost restriction factors in retroviral infection: promises in virus-host interaction
Retroviruses have an intricate life cycle. There is much to be learned from studying retrovirus-host interactions. Among retroviruses, the primate lentiviruses have one of the more complex genome structures wi...
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Article
Open AccessEvidence for Vpr-dependent HIV-1 Replication in Human CD4+CEM.NKR T-Cells
Vpr is exclusively expressed in primate lentiviruses and contributes to viral replication and disease progression in vivo. HIV-1 Vpr has two major activities in vitro: arrest of cell cycle in the G2 phase (G2 ...
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Article
Open AccessA novel HIV-1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR
Isolation of novel retroviral restriction factors will open new avenues for anti-HIV/AIDS treatment. Although HIV-1 replication is restricted by APOBEC3G/APOBEC3F, TRIM5α, and CD317, none defend HIV-1 infectio...
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Article
Open AccessIntracellular immunity to HIV-1: newly defined retroviral battles inside infected cells
Studies of the human immunodeficiency virus type 1 (HIV-1) continue to enrich eukaryotic biology and immunology. Recent advances have defined factors that function after viral entry and prevent the replication...
