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Article
PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury
Synchronized ferroptosis contributes to nephron loss in acute kidney injury (AKI). However, the propagation signals and the underlying mechanisms of the synchronized ferroptosis for renal tubular injury remain...
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Article
Integrative metabolomics dictate distinctive signature profiles in patients with Tetralogy of Fallot
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease (CCHD) with multifactorial etiology. We aimed to investigate the metabolic profiles of CCHD and their independent contributions to...
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Article
Open AccessThe HANTS-fitted RSEI constructed in the vegetation growing season reveals the spatiotemporal patterns of ecological quality
Yuxi, located in China’s central plateau of Yunnan, is grappling with ecological and environmental challenges as it continues to develop its economy. While ecological quality assessment serves as the foundatio...
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Article
1D Convolutional Seismic Event Classification Method Based on Attention Mechanism and Light Inception Block
Waveforms of artificially induced explosions and collapse events recorded by the seismic network share similarities with natural earthquakes. Failure to identify and screen them in a timely manner can introduc...
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Article
Open AccessRadiomics of pericoronary adipose tissue on computed tomography angiography predicts coronary heart disease in patients with type 2 diabetes mellitus
Diabetes is a common chronic metabolic disease. The progression of the disease promotes vascular inflammation and the formation of atherosclerosis, leading to cardiovascular disease. The coronary artery periva...
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Article
Open AccessGenome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic...
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Article
Correction to: Synthesis of Porous Polymer Based Solid Acid Catalyst towards Room Temperature Thioacetal/Thioketal Formation
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Article
NK cells as powerful therapeutic tool in cancer immunotherapy
Natural killer (NK) cells have gained considerable attention and hold great potential for their application in tumor immunotherapy. This is mainly due to their MHC-unrestricted and pan-specific recognition cap...
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Article
Association of combined healthy lifestyle factors with incident osteoporosis in patients with and without type 2 diabetes
The association between type 2 diabetes mellitus (T2DM), lifestyle factors, and the risk of osteoporosis (OP) is well-established. However, the impact of a healthy lifestyle on diabetes-related osteoporosis ne...
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Article
Open AccessAcod1/itaconate activates Nrf2 in pulmonary microvascular endothelial cells to protect against the obesity-induced pulmonary microvascular endotheliopathy
Obesity is the main risk factor leading to the development of various respiratory diseases, such as asthma and pulmonary hypertension. Pulmonary microvascular endothelial cells (PMVECs) play a significant role...
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Article
Comparison of total percutaneous in situ microneedle puncture and chimney technique for left subclavian artery fenestration in thoracic endovascular aortic repair for type B aortic dissection
To compare the outcomes of totally percutaneous in situ microneedle puncture for left subclavian artery (LSA) fenestration (ISMF) and chimney technique in type B aortic dissection (TBAD) during thoracic endova...
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Article
BQA: a high-performance quantum circuits scheduling strategy based on heuristic search
Quantum computing is currently a research hotspot in both academia and industry. The inherent parallelism of quantum computers and the resulting powerful computing power will bring new solutions to many proble...
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Article
Anomalous thermal expansion and enhanced magnetocaloric effect in <001>-textured MnxFe5–xSi3 alloys
The development of zero and negative thermal expansion (i.e., ZTE and NTE) materials is of crucial importance to the control of undesirable thermal expansion for high-precision devices. In the present work, ZT...
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Article
Open AccessCharacterization and evaluation of cytotoxic and antimicrobial activities of cyclotides from Viola japonica
Cyclotides are a type of defense peptide most commonly found in the Violaceae family of plants, exhibiting various biological activities. In this study, we focused on the Viola japonica as our research subject an...
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Article
Open AccessA new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers
Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 antibody named hIMB1636, and designated ...
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Article
Boosting ammonia production in electrocatalytic NOx reduction on a robust Fe/FeMoO4 catalyst
Electrocatalytic reduction of nitrate \(({\rm{N}}{{\rm{O}}_3}^ - )\) ( NO ...
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Article
Synthesis of Porous Polymer Based Solid Acid Catalyst Towards Room Temperature Thioacetal/Thioketal Formation
Both the alkyl sulfonic acid and phenyl sulfonic acid groups were incorporated onto a hypercrosslinked porous polymer through copolymerization and post-sulfonation to form novel PDVB-SO3H-SO3H catalyst. The porou...
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Article
Open AccessThiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity
During spaceflight, the cardiovascular system undergoes remarkable adaptation to microgravity and faces the risk of cardiac remodeling. Therefore, the effects and mechanisms of microgravity on cardiac morpholo...
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Article
Time-resolved ultra-small-angle X-ray scattering beamline (BL10U1) at SSRF
The construction of a new beamline, BL10U1, was completed at the Shanghai synchrotron radiation facility in 2020. This multipurpose beamline was designed to provide X-ray scattering techniques such as ultra-sm...
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Article
VO2@TiO2 Photocatalytic Switch
The sharp changes in optical and electrical properties in the VO2 metal–semiconductor phase transition are regarded as an on–off switch to regulate the photocatalytic performance of VO2@TiO2. As the switch is ON,...
