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  1. Article

    IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

    The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-limiting systemic inflammatory responses in humans that were not predicted from preclinical studies. Here, we show that t...

    Siri Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh… in Nature Immunology (2022)

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    Article

    CSF-1R inhibition alters macrophage polarization and blocks glioma progression

    The authors provide preclinical testing of a CSFR-1 inhibitor in proneural glioma models. The compound targets macrophages in the tumor microenvironment rather than tumor cells themselves and is shown to porte...

    Stephanie M Pyonteck, Leila Akkari, Alberto J Schuhmacher… in Nature Medicine (2013)

  3. Article

    Open Access

    Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivodetection of mammary tumors and multiple metastases in immune deficient mice

    Our goal was to generate xenograft mouse models of human breast cancer based on luciferase-expressing MDA-MB-231 tumor cells that would provide rapid mammary tumor growth; produce metastasis to clinically rele...

    Darlene E Jenkins, Yvette S Hornig, Yoko Oei, Joan Dusich… in Breast Cancer Research (2005)

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  4. No Access

    Article

    Bioluminescent imaging (BLI) to improve and refine traditional murine models of tumor growth and metastasis

    Bioluminescent imaging (BLI) permits sensitive in vivo detection and quantification of cells specifically engineered to emit visible light. Three stable human tumor cell lines engineered to express luciferase wer...

    Darlene E. Jenkins, Yoko Oei, Yvette S. Hornig… in Clinical & Experimental Metastasis (2003)