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Open AccessThe Neo-PLANET phase II trial of neoadjuvant camrelizumab plus concurrent chemoradiotherapy in locally advanced adenocarcinoma of stomach or gastroesophageal junction
The synergistic effect of neoadjuvant immunotherapy and chemoradiotherapy in gastric adenocarcinoma is unclear. This phase II trial (NCT03631615) investigated this neoadjuvant combination in locally advanced a...
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Article
Open AccessMultiplexed nanomaterial-assisted laser desorption/ionization for pan-cancer diagnosis and classification
As cancer is increasingly considered a metabolic disorder, it is postulated that serum metabolite profiling can be a viable approach for detecting the presence of cancer. By multiplexing mass spectrometry fing...
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Article
Open AccessDiesel2p mesoscope with dual independent scan engines for flexible capture of dynamics in distributed neural circuitry
Imaging the activity of neurons that are widely distributed across brain regions deep in scattering tissue at high speed remains challenging. Here, we introduce an open-source system with Dual Independent Enha...
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Open AccessStimulus-specific regulation of visual oddball differentiation in posterior parietal cortex
The frequency at which a stimulus is presented determines how it is interpreted. For example, a repeated image may be of less interest than an image that violates the prior sequence. This process involves inte...
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Article
Open AccessMice use robust and common strategies to discriminate natural scenes
Mice use vision to navigate and avoid predators in natural environments. However, their visual systems are compact compared to other mammals, and it is unclear how well mice can discriminate ethologically rele...
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Article
Open AccessInner membrane fusion mediates spatial distribution of axonal mitochondria
In eukaryotic cells, mitochondria form a dynamic interconnected network to respond to changing needs at different subcellular locations. A fundamental yet unanswered question regarding this network is whether ...