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Article
Glutamatergic Neurons in the Zona Incerta Modulate Pain and Itch Behaviors in Mice
Emerging evidence suggest that parvalbumin neurons in zona incerta (ZI) modulate pain and itch behavior in opposite manners. However, the role of ZI glutamatergic neurons, a unique incertal neuronal subpopulat...
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Article
Open AccessAntibody response and cross-neutralization after Omicron BA.2 infection
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Article
Graded-Three-Dimensional Cell-Encapsulating Hydrogel as a Potential Biologic Scaffold for Disc Tissue Engineering
Intervertebral disk (IVD) degeneration, which can cause lower back pain, is a major predisposing factor for disability and can be managed through multiple approaches. However, there is no satisfactory strategy...
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Article
Open AccessDeconstructing the intra-tumor subclonal heterogeneity of lung synchronous ground-glass nodules using whole-genome sequencing
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Article
Open AccessNuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells
The eukaryotic genome is folded into higher-order conformation accompanied with constrained dynamics for coordinated genome functions. However, the molecular machinery underlying these hierarchically organized...
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Article
Open AccessUSP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID
Activation-induced cytidine deaminase (AID) initiates class-switch recombination and somatic hypermutation (SHM) in antibody genes. Protein expression and activity are tightly controlled by various mechanisms....
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Open AccessSARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance
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Article
Open AccessInfection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission route
COVID-19 is identified as a zoonotic disease caused by SARS-CoV-2, which also can cross-transmit to many animals but not mice. Genetic modifications of SARS-CoV-2 or mice enable the mice susceptible to viral i...
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Article
Open AccessIdentification of novel key genes associated with the metastasis of prostate cancer based on bioinformatics prediction and validation
Metastatic prostate cancer (PCa) is a lethal tumor. However, the molecular mechanisms underlying PCa progression have not been fully elucidated.
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Article
Open AccessEngineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration
Long-lived plasma cells (LLPCs) are robust specialized antibody-secreting cells that mainly stay in the bone marrow and can persist a lifetime. As they can be generated by inducing the differentiation of B-lym...
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Article
Retraction Note to: Spinal circRNA-9119 Suppresses Nociception by Mediating the miR-26a-TLR3 Axis in a Bone Cancer Pain Mouse Model
The authors have retracted this article [1] because in further experiments, they found that some experimental data cannot be verified repeatedly.
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Article
Open AccessCorrection to: Analysis of dynamic molecular networks for pancreatic ductal adenocarcinoma progression
An amendment to this paper has been published and can be accessed via the original article.
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Article
Correction to: RETRACTED ARTICLE: Spinal circRNA-9119 Suppresses Nociception by Mediating the miR-26a-TLR3 Axis in a Bone Cancer Pain Mouse Model
The original version of this article unfortunately contained a mistake in Fig. 2.
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Article
RETRACTED ARTICLE: Spinal circRNA-9119 Suppresses Nociception by Mediating the miR-26a-TLR3 Axis in a Bone Cancer Pain Mouse Model
Altered expression of circular RNA (circRNA) is recognized as a contributor to malignant pain where microRNA (miRNA) exerts an essential effect. We generated a murine model for bone malignancy pain in which 24...
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Article
Segregated precuneus network and default mode network in naturalistic imaging
A resting-state network centered at the precuneus has been recently proposed as a precuneus network (PCUN) or “parietal memory network”. Due to its spatial adjacency and overlap** with the default mode netwo...
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Article
Open AccessAnalysis of dynamic molecular networks for pancreatic ductal adenocarcinoma progression
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumors. The rapid progression of PDAC results in an advanced stage of patients when diagnosed. However, the dynamic molecular mechanism und...
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Article
Open AccessDCZ3301, a novel cytotoxic agent, inhibits proliferation in diffuse large B-cell lymphoma via the STAT3 pathway
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in adults, characterized by a rapidly increasing painless mass. A novel compound, DCZ3301, was synthesized that exerted direct cytotoxi...